期刊
FRONTIERS IN NEURAL CIRCUITS
卷 15, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fncir.2021.659280
关键词
auditory cortex; corticothalamic; laser-induced ablation; Mongolian gerbil (Meriones unguiculatus); current-source density; intracortical microstimulation
资金
- Deutsche Forschungsgemeinschaft DFG [SFB779, SFB1436, 425899996]
The study demonstrates that lesioning the VI layer of corticothalamic (CT) neurons affects cortical frequency processing in the auditory cortex, while lesioning the V layer does not. In the auditory cortex, VI layer CT neurons have a specific impact on local feedforward frequency processing.
Corticofugal projections outnumber subcortical input projections by far. However, the specific role for signal processing of corticofugal feedback is still less well understood in comparisonto the feedforward projection. Here, we lesioned corticothalamic (CT) neurons in layers V and/or VI of the auditory cortex of Mongolian gerbils by laser-induced photolysis to investigate their contribution to cortical activation patterns. We have used laminar current-source density (CSD) recordings of tone-evoked responses and could show that, particularly, lesion of CT neurons in layer VI affected cortical frequency processing. Specifically, we found a decreased gain of best-frequency input in thalamocortical (TC)-recipient input layers that correlated with the relative lesion of layer VI neurons, but not layer V neurons. Using cortical silencing with the GABA(a)-agonist muscimol and layer-specific intracortical microstimulation (ICMS), we found that direct activation of infragranular layers recruited a local recurrent cortico-thalamo-cortical loop of synaptic input. This recurrent feedback was also only interrupted when lesioning layer VI neurons, but not cells in layer V. Our study thereby shows distinct roles of these two types of CT neurons suggesting a particular impact of CT feedback from layer VI to affect the local feedforward frequency processing in auditory cortex.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据