期刊
FRONTIERS IN CELLULAR NEUROSCIENCE
卷 15, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fncel.2021.680345
关键词
epidermis; somatosensory neuron; axon and dendrite development; C; elegans; Drosophila; zebrafish
资金
- National Institutes of Health [NINDS R01 NS076614, NICHD R00 HD086271]
- University of Washington Royalty Research Fund
- Fred Hutch/University of Washington Cancer Consortium [NCI P30 CA015704]
- University of Washington Diabetes Research Center [NIDDK P30 DK017047]
- Washington Research Foundation Postdoctoral Fellowship
- Weill Neurohub
- Washington Research Foundation
Recent research shows that epidermal signals play a crucial role in determining the patterns of somatosensory neuron innervation in the skin through various mechanisms, including targeting afferents to the epidermis, providing instructive cues for branching morphogenesis, and facilitating interactions between neurites.
Somatosensory neurons (SSNs) densely innervate our largest organ, the skin, and shape our experience of the world, mediating responses to sensory stimuli including touch, pressure, and temperature. Historically, epidermal contributions to somatosensation, including roles in shaping innervation patterns and responses to sensory stimuli, have been understudied. However, recent work demonstrates that epidermal signals dictate patterns of SSN skin innervation through a variety of mechanisms including targeting afferents to the epidermis, providing instructive cues for branching morphogenesis, growth control and structural stability of neurites, and facilitating neurite-neurite interactions. Here, we focus onstudies conducted in worms (Caenorhabditis elegans), fruit flies (Drosophila melanogaster), and zebrafish (Danio rerio): prominent model systems in which anatomical and genetic analyses have defined fundamental principles by which epidermal cells govern SSN development.
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