4.1 Review

Acromegaly: achieving timely diagnosis and improving outcomes by personalized care

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Clinical presentation and management of acromegaly in elderly patients

Filippo Ceccato et al.

Summary: Elderly patients with acromegaly are not uncommon, and primary medical therapy is a reasonable option with effective results, while the rate of surgical success is not reduced. A careful cost-benefit balance is suggested. Disease-specific comorbidities are more prevalent in acromegalic patients with a longer follow-up rather than in those diagnosed aged >= 65 years.

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Quality of Life and its Determinants in Patients With Treated Acromegaly: A Cross-Sectional Nationwide Study in China

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Summary: The study found that although biochemical control improved in treated acromegaly patients, quality of life (QoL) remained impaired. The number of symptoms and comorbidities, gender, radiotherapy, and medical treatment with somatostatin analogs were identified as factors influencing QoL in these patients.

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Increased risk of preneoplastic colonic lesions and colorectal carcinoma in acromegaly: multicenter case-control study

Maria Florencia Battistone et al.

Summary: The study found an increased risk of preneoplastic colonic lesions and colorectal carcinoma in patients with acromegaly compared to a control group, with insulin resistance being the only statistically significant associated factor among patients with colonic polyps. The results support the recommendation to perform screening colonoscopy at the time of diagnosis of acromegaly.

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Summary: This article focuses on recent advances in the management of acromegaly, emphasizing how key developments affect treatment decisions and outcomes. It also explores the potential role of recently FDA-approved therapies and combination therapies in the treatment arsenal.

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Sex differences in acromegaly at diagnosis: A nationwide cohort study and meta-analysis of the literature

Jakob Dal et al.

Summary: There are only minor differences in the epidemiology of acromegaly at the time of diagnosis between genders, except for the fact that female patients tend to be slightly older, have lower IGF-I concentrations, and experience longer diagnostic delays.

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Summary: A systematic review and meta-analysis of treatment effects on symptoms and health-related quality of life (HRQoL) in acromegaly found that both symptoms and HRQoL improved during treatment, with potential consensus needed on which symptoms to include in a core outcome set for clinical use and trials.

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Carpal tunnel syndrome in acromegaly: a nationwide study

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Summary: Carpal tunnel syndrome (CTS) is common in patients with acromegaly, with a prevalence of 19-64%. A study in Sweden found that patients with acromegaly had a 6-fold higher incidence for CTS surgery before the diagnosis of acromegaly compared with the general population. Women with acromegaly had a higher risk for CTS than men.

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Incidentally detected acromegaly: single-center study of surgically treated patients over 22 years

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Summary: In recent years, an increased number of patients with GH-secreting adenomas were incidentally detected (ID). The ID group and CP group showed differences in clinical, biochemical, and radiological characteristics, but had similar 3-month biochemical remission rates and rates of normal IGF-1 levels after surgery.

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A Consensus on the Diagnosis and Treatment of Acromegaly Comorbidities: An Update

Andrea Giustina et al.

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Effects of Pegvisomant and Pasireotide LAR on Vertebral Fractures in Acromegaly Resistant to First-generation SRLs

Sabrina Chiloiro et al.

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The Course of Obstructive Sleep Apnea Syndrome in Patients With Acromegaly During Treatment

Thalijn L. C. Wolters et al.

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Biochemical Control in Acromegaly With Multimodality Therapies: Outcomes From a Pituitary Center and Changes Over Time

Alireza Ghajar et al.

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Obstructive Sleep Apnea in Acromegaly and the Effect of Treatment: A Systematic Review and Meta-Analysis

Matteo Parolin et al.

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The effect of treatment on quality of life in patients with acromegaly: a prospective study

T. L. C. Wolters et al.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2020)

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MANAGEMENT OF ENDOCRINE DISEASE Does gender matter in the management of acromegaly?

Nele F. Lenders et al.

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Risk for Acromegaly-related Comorbidities by Sex in Korean Acromegaly

Kyeong Hye Park et al.

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Prolonged diagnostic delay in acromegaly is associated with increased morbidity and mortality

Daniela Esposito et al.

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Progression of vertebral fractures in long-term controlled acromegaly: a 9-year follow-up study

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Treatment of Acromegalic Osteopathy in Real-life Clinical Practice: The BAAC (Bone Active Drugs in Acromegaly) Study

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Metabolic complications in acromegaly after neurosurgery: a meta-analysis

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Surgical and Pharmacological Outcomes in Acromegaly: Real-Life Data From the Mexican Acromegaly Registry

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Maintenance of Acromegaly Control in Patients Switching From Injectable Somatostatin Receptor Ligands to Oral Octreotide

Susan L. Samson et al.

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Multidisciplinary management of acromegaly: A consensus

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Risk factors and management of pasireotide-associated hyperglycemia in acromegaly

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Acromegaly in the elderly patients

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Pegvisomant Improves Glucose Metabolism in Acromegaly: A Meta-Analysis of Prospective Interventional Studies

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Use of administrative health databases to estimate incidence and prevalence of acromegaly in Piedmont Region, Italy

M. Caputo et al.

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AcroVoice: eliciting the patients' perspective on acromegaly disease activity

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Age- and Sex-Specific Differences as Predictors of Surgical Remission Among Patients With Acromegaly

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Persistence of Diabetes and Hypertension After Multimodal Treatment of Acromegaly

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Somatostatin Analogs and Glucose Metabolism in Acromegaly: A Meta-Analysis of Prospective Interventional Studies

Alessia Cozzolino et al.

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Acromegaly: clinical features at diagnosis

Lucio Vilar et al.

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Epidemiology of acromegaly: review of population studies

Aikaterini Lavrentaki et al.

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Acromegaly at diagnosis in 3173 patients from the Liege Acromegaly Survey (LAS) Database

Patrick Petrossians et al.

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Changes in the management and comorbidities of acromegaly over three decades: the French Acromegaly Registry

Luigi Maione et al.

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ACROSCORE: a new and simple tool for the diagnosis of acromegaly, a rare and underdiagnosed disease

Nunzia Prencipe et al.

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Mortality in acromegaly: a 20-year follow-up study

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Diagnosis and management of acromegaly: the patient's perspective

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Symptoms and signs of acromegaly: an ongoing need to raise awareness among healthcare practitioners

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Acromegaly: An Endocrine Society Clinical Practice Guideline

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Long-term outcome in patients with acromegaly: analysis of 1344 patients from the German Acromegaly Register

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