期刊
RECENT PATENTS ON NANOTECHNOLOGY
卷 17, 期 1, 页码 15-17出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1872210515666210720130736
关键词
Coronavirus; COVID-19; liposome; nanovaccine; SARS-CoV-2; viral outbreak
The COVID-19 pandemic has caused a global outbreak, and there are over 100 different vaccines being investigated, including DNA vaccines, inactivated virus vaccines, and adenovirus-based vaccines. Inactivated virus vaccines and mRNA, adenovirus-based vaccines have entered clinical trials.
Background: The novel coronavirus 2019 (COVID-19) infection has caused the global emergence of coronavirus in humans during the last 12 months. Till May 11, 2021, the confirmed global COVID-19 cases and deaths reached 158551526 and 3296855, respectively. Methods: Goblet cells and ciliated cells in the nose act as the initial infection site of SARS-CoV-2. Thus, mucus immunity is important to protect from infection. The outburst of SARS-CoV-2 infection can be halted only when an effective vaccine will be developed. Results: Globally, over 100 different vaccines are under investigation, including DNA vaccines, RNA vaccines, inactivated virus vaccines, adenovirus-based vaccines, recombinant/subunit protein vaccines, peptide vaccines, virus-like particles, etc. Inactivated virus vaccines and mRNA, and adenovirus-based vaccines have moved fast into patent clinical trials. Conclusion: Vaccines containing spike protein of SARS-CoV as subunit could effectively prevent binding of coronavirus to the host cell and membrane fusion. Thus, spike protein can be used as a major target for subunit vaccine preparation.
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