期刊
VIRUSES-BASEL
卷 13, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/v13081592
关键词
duck hepatitis A virus; recombination; Hungary
类别
资金
- Hungarian Scientific Research Fund [K120201]
The study revealed intragenotype and intergenotype recombination events in DHAV-1 strains, particularly in the VP0 region. DHAV-1 exhibited slightly lower rates of evolution compared to other picornaviruses, with diversifying selection acting on specific genomic regions. Whole-genome-based analysis of DHAV strains is necessary for a better understanding of novel strain emergence and geographic dispersal.
Duck hepatitis A virus (DHAV), an avian picornavirus, causes high-mortality acute disease in ducklings. Among the three serotypes, DHAV-1 is globally distributed, whereas DHAV-2 and DHAV-3 serotypes are chiefly restricted to Southeast Asia. In this study, we analyzed the genomic evolution of DHAV-1 strains using extant GenBank records and genomic sequences of 10 DHAV-1 strains originating from a large disease outbreak in 2004-2005, in Hungary. Recombination analysis revealed intragenotype recombination within DHAV-1 as well as intergenotype recombination events involving DHAV-1 and DHAV-3 strains. The intergenotype recombination occurred in the VP0 region. Diversifying selection seems to act at sites of certain genomic regions. Calculations estimated slightly lower rates of evolution of DHAV-1 (mean rates for individual protein coding regions, 5.6286 x 10(-4) to 1.1147 x 10(-3) substitutions per site per year) compared to other picornaviruses. The observed evolutionary mechanisms indicate that whole-genome-based analysis of DHAV strains is needed to better understand the emergence of novel strains and their geographical dispersal.
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