期刊
VIRUSES-BASEL
卷 13, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/v13091818
关键词
hantavirus; puumala virus; HFRS; hormonal defect; AKI; hypogonadism; hypothyroidism; coagulation; fibrinolysis
类别
资金
- Tampere University Hospital [5900/3225, 9V025]
- Medical Research Fund of Seinajoki Central Hospital [6000/3231]
During acute Puumala virus infection, hormonal deficiencies are common among patients, with 80% of men exhibiting clinical hypogonadism and approximately 20% having hypothyroidism. Acute peripheral hormone deficits are associated with severe kidney injury, longer hospital stay, and more severe thrombocytopenia.
Central and peripheral hormone deficiencies have been documented during and after acute hantavirus infection. Thrombocytopenia and coagulation abnormalities are common findings in haemorrhagic fever with renal syndrome (HFRS). The associations between coagulation and hormonal abnormalities in HFRS have not been studied yet. Forty-two patients diagnosed with Puumala virus (PUUV) infection were examined during the acute phase and on a follow-up visit approximately one month later. Hormonal defects were common during acute PUUV infection. Overt (clinical) hypogonadism was identified in 80% of the men and approximately 20% of the patients had overt hypothyroidism. At the one-month follow-up visit, six patients had central hormone deficits. Acute peripheral hormone deficits associated with a more severe acute kidney injury (AKI), longer hospital stay and more severe thrombocytopenia. Half of the patients with bleeding symptoms had also peripheral hormonal deficiencies. Patients with free thyroxine levels below the reference range had higher D-dimer level than patients with normal thyroid function, but no thromboembolic events occurred. Acute phase hormonal abnormalities associate with severe disease and altered haemostasis in PUUV infection.
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