期刊
VIRUSES-BASEL
卷 13, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/v13061132
关键词
rodents; hantavirus; monitoring; population dynamics; common vole; field vole; water vole; phylogeny; molecular evolution
类别
资金
- Federal Environment Agency (UBA) [3709 41 401, 3713 48 401]
- Federal Ministry of Education and Research (BMBF) within the Research net Zoonotic Infectious Diseases (consortium RoBoPub) [01KI1721A, 01KI2004A, 01KI2004E]
- Robert Koch Institute
- German Ministry of Public Health [1362/1-924, 1362/1-980]
- Deutsche Forschungsgemeinschaft (SPP 1596, Ecology and Species Barriers in Emerging Viral Diseases) [UL 405/1-1]
- EMIDA ERA-NET project APHAEA [2811ERA117]
- Swiss National Science Foundation [31003A_176209]
- EU [FP7-261504 EDENext]
- Swiss National Science Foundation (SNF) [31003A_176209] Funding Source: Swiss National Science Foundation (SNF)
Tula orthohantavirus (TULV) is a rodent-borne hantavirus with broad distribution in Europe, primarily hosted by the common vole. Factors at individual and population levels of hosts were found to be significant predictors of TULV dynamics. Different phylogenetic TULV clades were detected on a large geographic scale, while on a small scale, this depended on the study area.
Tula orthohantavirus (TULV) is a rodent-borne hantavirus with broad geographical distribution in Europe. Its major reservoir is the common vole (Microtus arvalis), but TULV has also been detected in closely related vole species. Given the large distributional range and high amplitude population dynamics of common voles, this host-pathogen complex presents an ideal system to study the complex mechanisms of pathogen transmission in a wild rodent reservoir. We investigated the dynamics of TULV prevalence and the subsequent potential effects on the molecular evolution of TULV in common voles of the Central evolutionary lineage. Rodents were trapped for three years in four regions of Germany and samples were analyzed for the presence of TULV-reactive antibodies and TULV RNA with subsequent sequence determination. The results show that individual (sex) and population-level factors (abundance) of hosts were significant predictors of local TULV dynamics. At the large geographic scale, different phylogenetic TULV clades and an overall isolation-by-distance pattern in virus sequences were detected, while at the small scale (<4 km) this depended on the study area. In combination with an overall delayed density dependence, our results highlight that frequent, localized bottleneck events for the common vole and TULV do occur and can be offset by local recolonization dynamics.
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