期刊
VIRUSES-BASEL
卷 13, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/v13071407
关键词
poliovirus; oral poliovirus vaccine; vaccine-derived poliovirus; immunodeficiency-associated vaccine-derived poliovirus; global polio eradication
类别
资金
- Research Program on Emerging and Re-emerging Infectious Diseases from the Japan Agency for Medical Research and Development [JP21fk0108084]
The use of oral poliovirus vaccine (OPV) has been crucial for preventing person-to-person transmission of poliovirus, but challenges such as cVDPV2 and iVDPV infections pose risks for global polio eradication efforts. The identification of chronic type 2 iVDPV (iVDPV2) excretors highlights the potential risk of inapparent iVDPV infection for expanding cVDPV outbreaks. Further research on genetic characterizations and molecular evolution of iVDPV2 will be critical for elucidating the remaining risk of iVDPV2 in the post-OPV era.
The oral poliovirus vaccine (OPV), which prevents person-to-person transmission of poliovirus by inducing robust intestinal immunity, has been a crucial tool for global polio eradication. However, polio outbreaks, mainly caused by type 2 circulating vaccine-derived poliovirus (cVDPV2), are increasing worldwide. Meanwhile, immunodeficiency-associated vaccine-derived poliovirus (iVDPV) is considered another risk factor during the final stage of global polio eradication. Patients with primary immunodeficiency diseases are associated with higher risks for long-term iVDPV infections. Although a limited number of chronic iVDPV excretors were reported, the recent identification of a chronic type 2 iVDPV (iVDPV2) excretor in the Philippines highlights the potential risk of inapparent iVDPV infection for expanding cVDPV outbreaks. Further research on the genetic characterizations and molecular evolution of iVDPV2, based on comprehensive iVDPV surveillance, will be critical for elucidating the remaining risk of iVDPV2 during the post-OPV era.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据