期刊
VIRUSES-BASEL
卷 13, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/v13071347
关键词
neutralizing activity; SARS-CoV-2; variants of concern
类别
资金
- European Virus Archive goes Global (EVAg) project - European Union's Horizon 2020 research and innovation programme [653316]
The study found that patients previously infected with SARS-CoV-2 showed a general decrease in neutralizing antibody titers when facing viral variants, especially against P.1 and B.1.351; this suggests that previous infection may not fully protect against the impact of the variants.
The recent spreading of new SARS-CoV-2 variants, carrying several mutations in the spike protein, could impact immune protection elicited by natural infection or conferred by vaccination. In this study, we evaluated the neutralizing activity against the viral variants that emerged in the United Kingdom (B.1.1.7), Brazil (P.1), and South Africa (B.1.351) in human serum samples from hospitalized patients infected by SARS-CoV-2 during the first pandemic wave in Italy in 2020. Of the patients studied, 59.5% showed a decrease (>= 2 fold) in neutralizing antibody titer against B.1.1.7, 83.3% against P.1, and 90.5% against B.1.351 with respect to the original strain. The reduction in antibody titers against all analyzed variants, and in particular P.1 and B.1.351, suggests that previous symptomatic infection might be not fully protective against exposure to SARS-CoV-2 variants carrying a set of relevant spike mutations.
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