4.6 Article

Nedd8-Activating Enzyme Is a Druggable Host Dependency Factor of Human and Mouse Cytomegalovirus

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Summary: The study identified 133 proteins degraded during early HCMV infection, with most rescued by MG132 and bortezomib, indicating the predominant role of proteasome in protein degradation by HCMV. This research provides insight into viral biology and potential antiviral therapeutic strategies by investigating mechanisms of host protein degradation.

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