Coagulopathy in Acute Puumala Hantavirus Infection

Puumala hantavirus (PUUV) causes a hemorrhagic fever with renal syndrome (HFRS), also called nephropathia epidemica (NE), which is mainly endemic in Europe and Russia. The clinical features include a low platelet count, altered coagulation, endothelial activation, and acute kidney injury (AKI). Multiple connections between coagulation pathways and inflammatory mediators, as well as complement and kallikrein-kinin systems, have been reported. The bleeding symptoms are usually mild. PUUV-infected patients also have an increased risk for disseminated intravascular coagulation (DIC) and thrombosis.

Automated summary

Puumala hantavirus, mainly endemic in Europe and Russia, causes hemorrhagic fever with renal syndrome, characterized by low platelet count, altered coagulation, endothelial activation, and acute kidney injury. Patients may experience mild bleeding symptoms and have an increased risk of disseminated intravascular coagulation (DIC) and thrombosis.