期刊
VIRUSES-BASEL
卷 13, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/v13060996
关键词
SARS-CoV-2; neutralizing antibodies; immunity
类别
资金
- Jane and Aatos Erkko Foundation
- EU Horizon [874735]
- Academy of Finland
- Helsinki University Hospital Funds [TYH2018322]
Newly emerged SARS-CoV-2 variants of concern show resistance to neutralization by antibodies elicited by the wild-type virus, with VoC2 having increased potential to reinfect previously SARS-CoV-infected individuals. Neutralizing antibodies in recovered patients show varied levels of inhibition against different variants, with some sera failing to neutralize VoC2.
Increasing evidence suggests that some newly emerged SARS-CoV-2 variants of concern (VoCs) resist neutralization by antibodies elicited by the early-pandemic wild-type virus. We applied neutralization tests to paired recoveree sera (n = 38) using clinical isolates representing the first wave (D614G), VoC1, and VoC2 lineages (B.1.1.7 and B 1.351). Neutralizing antibodies inhibited contemporary and VoC1 lineages, whereas inhibition of VoC2 was reduced 8-fold, with 50% of sera failing to show neutralization. These results provide evidence for the increased potential of VoC2 to reinfect previously SARS-CoV-infected individuals. The kinetics of NAbs in different patients showed similar decline against all variants, with generally low initial anti-B.1.351 responses becoming undetectable, but with anti-B.1.1.7 NAbs remaining detectable (>20) for months after acute infection.
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