期刊
VIRUSES-BASEL
卷 13, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/v13061135
关键词
SARS-CoV-2; humoral response; pseudovirus; neutralization; B; 1; 1; 7 variant
类别
资金
- Grifols
- Departament de Salut of the Generalitat de Catalunya [SLD016, SLD015]
- Spanish Health Institute Carlos III [PI17/01518, PI20/00093, PI18/01332]
- CERCA Programme/Generalitat de Catalunya [2017 SGR 252]
- joemcorono
- BonPreu/Esclat
- Correos
- National Agency for Research and Development of Chile (ANID) [72180406]
The study found that the time from natural infection and the nature of the infecting variant determined cross-neutralization; Uninfected vaccinees showed a small reduction in neutralization against the B.1.1.7 variant; Previously infected individuals developed more robust neutralizing responses against B.1.1.7 after vaccination, indicating that vaccines can enhance the neutralization breadth conferred by natural infection.
With the spread of new variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), there is a need to assess the protection conferred by both previous infections and current vaccination. Here we tested the neutralizing activity of infected and/or vaccinated individuals against pseudoviruses expressing the spike of the original SARS-CoV-2 isolate Wuhan-Hu-1 (WH1), the D614G mutant and the B.1.1.7 variant. Our data show that parameters of natural infection (time from infection and nature of the infecting variant) determined cross-neutralization. Uninfected vaccinees showed a small reduction in neutralization against the B.1.1.7 variant compared to both the WH1 strain and the D614G mutant. Interestingly, upon vaccination, previously infected individuals developed more robust neutralizing responses against B.1.1.7, suggesting that vaccines can boost the neutralization breadth conferred by natural infection.
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