期刊
WOUND REPAIR AND REGENERATION
卷 29, 期 4, 页码 642-649出版社
WILEY
DOI: 10.1111/wrr.12939
关键词
autophagy; fibroblast-like synoviocytes; myofibroblasts; osteoarthritis; synovial fibrosis; synovium
资金
- Canadian Institute of Health Research Operating grant [156299]
- Tier 1 Canada Research Chair Award [950-232237]
- Tony and Shari Fell Platinum Chair in Arthritis Research
This review discusses the activation of fibroblast-like synoviocytes and their role in driving fibrotic responses in osteoarthritis, as well as the impact of myofibroblast-like cells on the structure of the synovial membrane.
The synovial membrane undergoes a variety of structural changes throughout the pathogenesis of osteoarthritis (OA), including the development of fibrosis. Fibroblast-like synoviocytes (FLS) are a heterogenous cell population of the synovium that are suggested to drive the fibrotic response, but the exact mechanisms associated with their activation in OA remain unclear. Once activated, FLS are suggested to acquire a myofibroblast-like phenotype that drives fibrogenesis through excessive extracellular matrix (ECM) component deposition and an enhanced contractile function. In this review, we define FLS in the synovium, discuss how select extracellular or endogenous factors potentially induce their activation in OA, and describe how the activity of myofibroblast-like cells affects the structure of the synovial membrane.
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