期刊
WORLD JOURNAL OF SURGICAL ONCOLOGY
卷 19, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12957-021-02303-5
关键词
Symptomatic anastomotic leakage; Risk factors; Long-term survival; Laparoscopic low anterior resection; Rectal cancer
资金
- National Natural Science Foundation of China [81672439, 81272766, 81450028]
- Beijing Natural Science Foundation [7162039]
- Capital's Funds for Health Improvement and Research [CFH 2018-2-2153]
- Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support [XM201309, ZYLX201701]
- Beijing Municipal Administration of Hospitals Incubating Program [PX 2016018]
- Beijing Excellent Talent Training Funding [2018000021469G258]
Prolonged duration of operation increased the risk of symptomatic AL after laparoscopic LAR for rectal cancer. No impact of symptomatic AL on long-term survival was observed in this study. Further studies are required for a conclusive result.
Background: Postoperative symptomatic anastomotic leakage (AL) is a serious complication after low anterior resection (LAR) for rectal cancer. AL can potentially affect short-term patient outcomes and long-term prognosis. This study aimed to explore the risk factors and long-term survival of symptomatic AL after laparoscopic LAR for rectal cancer. Methods: From May 2009 to May 2015, 298 consecutive patients who underwent laparoscopic LAR for rectal cancer with or without a defunctioning stoma were included in this study. Univariate and multivariate logistic regression analyses were used to explore independent risk factors for symptomatic AL. Survival analysis was performed using Kaplan-Meier curves, and log-rank tests were used for group comparisons. Results: Among the 298 patients enrolled in this study, symptomatic AL occurred in eight (2.7%) patients. The univariate analysis showed that age of <= 65 years (P = 0.048), neoadjuvant therapy (P = 0.095), distance from the anal verge (P = 0.078), duration of operation (P = 0.001), and pathological tumor (T) category (P = 0.004) were associated with symptomatic AL. The multivariate analysis demonstrated that prolonged duration of operation (P = 0.010) was an independent risk factor for symptomatic AL after laparoscopic LAR for rectal cancer. No statistically significant differences were observed in the 3-year (P = 0.785) and 5-year (P = 0.979) overall survival rates. Conclusions: A prolonged duration of operation increased the risk of symptomatic AL after laparoscopic LAR for rectal cancer. An impact of symptomatic AL on a long-term survival was not observed in this study; however, further studies are required.
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