期刊
出版社
WILEY
DOI: 10.1002/wnan.1740
关键词
contrast agents; iron oxide nanoparticles; magnetic resonance imaging; ultrasmall
资金
- National Key Research and Development Program of China [2018YFA0208800]
- National Natural Science Foundation of China [81720108024]
- Natural Science Foundation of Jiangsu Province [BK20191418]
- Nature Science Foundation of Jiangsu Higher Education Institutions of China [20KJA150006]
- Priority Academic Program Development of Jiangsu Higher Education Institutions, PAPD
- Suzhou Key Industry Technology Innovation Projects [SYG202036]
USPIO nanoparticles, with their excellent MRI performance and remarkable biosafety profile, have shown considerable applications in developing T-1 contrast agents and T-2/T-1 switchable contrast agents, and have been widely used in the diagnosis of vascular pathological changes, inflammations, and malignant tumors.
As a research hotspot, the development of magnetic resonance imaging (MRI) contrast agents has attracted great attention over the past decades for improving the accuracy of diagnosis. Ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles with core diameter smaller than 5.0 nm are expected to become a next generation of contrast agents owing to their excellent MRI performance, long blood circulation time upon proper surface modification, renal clearance capacity, and remarkable biosafety profile. On top of these merits, USPIO nanoparticles are used for developing not only T-1 contrast agents, but also T-2/T-1 switchable contrast agents via assembly/disassembly approaches. In recent years, as a new type of contrast agents, USPIO nanoparticles have shown considerable applications in the diagnosis of various diseases such as vascular pathological changes and inflammations apart from malignant tumors. In this review, we are focusing on the state-of-the-art developments and the latest applications of USPIO nanoparticles as MRI contrast agents to discuss their advantages and future prospects. This article is categorized under: Diagnostic Tools > In Vivo Nanodiagnostics and Imaging
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