Recent advances and applications of microspheres and nanoparticles in transarterial chemoembolization for hepatocellular carcinoma

Transarterial chemoembolization (TACE) is a recommended treatment for patients suffering from intermediate and advanced hepatocellular carcinoma (HCC). As compared to the conventional TACE, drug-eluting bead TACE demonstrates several advantages in terms of survival, treatment response, and adverse effects. The selection of embolic agents is critical to the success of TACE. Many studies have been performed on the modification of the structure, size, homogeneity, biocompatibility, and biodegradability of embolic agents. Continuing efforts are focused on efficient loading of versatile chemotherapeutics, controlled sizes for sufficient occlusion, real-time detection intra- and post-procedure, and multimodality imaging-guided precise treatment. Here, we summarize recent advances and applications of microspheres and nanoparticles in TACE for HCC. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease

Automated summary

Transarterial chemoembolization (TACE) is a recommended treatment for patients with intermediate and advanced hepatocellular carcinoma (HCC), with drug-eluting bead TACE showing advantages over conventional TACE in terms of survival, treatment response, and adverse effects. The selection of embolic agents is critical to TACE success, with ongoing research focusing on modifying their structure, size, homogeneity, biocompatibility, and biodegradability for improved outcomes.