期刊
WATER RESEARCH
卷 198, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.watres.2021.117183
关键词
SARS-CoV-2; Particle integrity; Quantification; Wastewater; Infectious risk
资金
- French ministery of research and innovation, Eau de Paris
- French armed forces biomedical research institute (IRBA), Sorbonne university
- CNRS
SARS-CoV-2 virus can be detected not only in respiratory droplets but also in human feces, urine, and raw wastewaters, suggesting possible alternative routes of infection. Monitoring virus genomes in wastewater can complement tracking virus transmission within the human population.
The ongoing global pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been a public health emergency of international concern. Although SARS-CoV-2 is considered to be mainly transmitted by inhalation of contaminated droplets and aerosols, SARS-CoV-2 is also detected in human feces and to a less extent in urine, and in raw wastewaters (to date viral RNA only) suggesting that other routes of infection may exist. Monitoring SARS-CoV2 genomes in wastewaters has been proposed as a complementary approach for tracing the dynamics of virus transmission within human population connected to wastewater network. The understanding on SARS-CoV-2 transmission through wastewater surveillance, the development of epidemic modeling and the evaluation of SARS-CoV-2 transmission from contaminated wastewater are largely limited by our knowledge on viral RNA genome persistence and virus infectivity preservation in such an environment. Using an integrity based RT-qPCR assay this study led to the discovery that SARS-CoV-2 RNA can persist under several forms in wastewaters, which provides important information on the presence of SARS-CoV2 in raw wastewaters and associated risk assessment. (c) 2021 Elsevier Ltd. All rights reserved.
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