期刊
VIROLOGY JOURNAL
卷 18, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12985-021-01611-2
关键词
Flavivirus; Envelope protein; Key amino acids; Viral attachment; Viral entry
类别
资金
- National Key Research and Development Program of China [2017YFD0500800]
- Sichuan-International joint research for science and technology [2018HH0098]
- China Agricultural Research System [CARS-42-17]
- Program Sichuan Veterinary Medicine and Drug Innovation Group of China Agricultural Research System (CARS-SVDIP)
- Integration and Demonstration of Key Technologies for Goose Industrial Chain in Sichuan Province [2018NZ0005]
Flaviviruses infect hosts through envelope proteins, which mainly bind to cell attachment receptors and endocytic receptors. Key envelope protein amino acids, mainly located in specific regions of the protein structure, play important roles in the early infection process by potentially affecting interactions between different domains. Some of these amino acids are involved in conformational changes in envelope proteins during viral entry.
Flaviviruses are enveloped viruses that infect multiple hosts. Envelope proteins are the outermost proteins in the structure of flaviviruses and mediate viral infection. Studies indicate that flaviviruses mainly use envelope proteins to bind to cell attachment receptors and endocytic receptors for the entry step. Here, we present current findings regarding key envelope protein amino acids that participate in the flavivirus early infection process. Among these sites, most are located in special positions of the protein structure, such as the alpha -helix in the stem region and the hinge region between domains I and II, motifs that potentially affect the interaction between different domains. Some of these sites are located in positions involved in conformational changes in envelope proteins. In summary, we summarize and discuss the key envelope protein residues that affect the entry process of flaviviruses, including the process of their discovery and the mechanisms that affect early infection.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据