期刊
VETERINARY PATHOLOGY
卷 58, 期 5, 页码 952-963出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/03009858211023946
关键词
astrocytoma; brain; dogs; cancer; immunohistochemistry; immunology; lymphocytes; macrophages; oligodendroglioma
资金
- North Carolina State University's College of Veterinary Medicine
- NIEHS/NTP
- Charles River Laboratories
Immune evasion is crucial in the pathogenesis of glioma, with canine glioma showing a robust immune cell infiltrate. Different numbers of specific cells were found in low-grade and high-grade gliomas, suggesting potential therapeutic targets for repolarization of macrophages or Treg interference in canine glioma.
Evasion of the immune response is an integral part of the pathogenesis of glioma. In humans, important mechanisms of immune evasion include recruitment of regulatory T cells (Tregs) and polarization of macrophages toward an M2 phenotype. Canine glioma has a robust immune cell infiltrate that has not been extensively characterized. The purpose of this study was to determine the distribution of immune cells infiltrating spontaneous intracranial canine gliomas. Seventy-three formalin-fixed, paraffin-embedded tumor samples were evaluated using immunohistochemistry for CD3, forkhead box 3 (FOXP3), CD20, Iba1, calprotectin (Mac387), CD163, and indoleamine 2,3-dioxygenase (IDO). Immune cell infiltration was present in all tumors. Low-grade and high-grade gliomas significantly differed in the numbers of FoxP3+ cells, Mac387+ cells, and CD163+ cells (P = .006, .01, and .01, respectively). Considering all tumors, there was a significant increase in tumor area fraction of CD163 compared to Mac387 (P < .0001), and this ratio was greater in high-grade tumors than in low-grade tumors (P = .005). These data warrant further exploration into the roles of macrophage repolarization or Treg interference therapy in canine glioma.
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