期刊
ACTA TROPICA
卷 141, 期 -, 页码 310-314出版社
ELSEVIER
DOI: 10.1016/j.actatropica.2014.08.001
关键词
Schistosoma mekongi; Schistosoma mansoni; Serodiagnosis; ELISA; Kato-Katz; Laos
资金
- International Development Research Centre
- Foreign Affairs, Trade and Development Canada (through the Global Health Research Initiative)
- Australian Agency for International Development [105509-027]
Northern Cambodia and Southern Laos are highly endemic for Schistosoma mekongi. However, there is currently no immunological assay available that is specific for this form of schistosomiasis. We have validated Schistosoma mansoni antigens to detect S. mekongi-directed antibodies in human sera collected from a highly S. mekongi endemic region in Laos. On two consecutive days stool samples of 234 individuals were analyzed by Kato-Katz for presence of S. mekongi eggs and the results were correlated with serology. A sensitivity of 94.5% was calculated for a combination of ELISA and indirect fluorescence assay (IFA) as compared to the detection of S. mekongi eggs in stool samples as gold standard. The results demonstrate that S. mansoni antigens can be used for the diagnosis of S. mekongi infections. (C) 2014 Elsevier B.V. All rights reserved.
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