期刊
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
卷 40, 期 12, 页码 525-536出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.urolonc.2021.04.041
关键词
Collecting duct carcinoma; Renal cell carcinoma; Non-clear cell renal cell carcinoma; Diagnostic criteria; Differential diagnosis; Clinical management
Collecting duct carcinoma is a rare and aggressive subtype of renal cell carcinoma, and its diagnosis is challenging due to evolving diagnostic criteria and lack of consistent molecular alterations.
Collecting duct carcinoma of the kidney is a rare and aggressive subtype of renal cell carcinoma (RCC) arising from the distal convoluted tubules. At the time of diagnosis, patients are more frequently symptomatic, with advanced locoregional stage, and have metastatic disease. The 2016 WHO Classification of Tumours of the Urinary System defined diagnostic criteria for this entity. However, the diagnostic features continue to evolve, with typical, but not entirely specific, histologic and immunophenotypic characteristics. In addition, the lack of consis-tent molecular alterations makes collecting duct carcinoma a diagnosis of exclusion, with historical cases being re-classified as fumarate hydratase deficient RCC, ALK rearranged RCC, renal medullary carcinoma or high-grade urothelial carcinoma. The rarity and poor progno-sis of the tumor makes it difficult to reach consensus guidelines to guide therapy. In this manuscript we review the clinicopathologic features of collecting duct carcinoma including pathologic diagnostic criteria, molecular characteristics and differential diagnosis, and their possible implications for management. (c) 2021 Elsevier Inc. All rights reserved.
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