期刊
ULTRASONICS SONOCHEMISTRY
卷 76, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.ultsonch.2021.105617
关键词
Targeted drug delivery; Human serum albumin; Proteinaceous nanocapsules; Sonochemical preparation
This study focuses on preparing proteinaceous human serum albumin (HSA) nanocapsules with biocompatible plant oil cores and embedded wheat germ agglutinin (WGA) as a targeting molecule, showing promising cell binding potential for innovative formulations.
The focus of this study is the preparation of proteinaceous human serum albumin (HSA) nanocapsules with biocompatible plant oil cores avoiding toxic cross-linker and noxious non-aqueous liquids. The sonochemical preparation of HSA capsules with different plant oils yields particles with narrow size distribution forming suspensions stable for at least 14 days and enabling long-term storage by freezing. Furthermore, wheat germ agglutinin (WGA) as a targeting molecule was successfully embedded into the proteinaceous particle shell at a molar ratio of 7:1 (HSA/WGA). As urothelial cell binding studies revealed up to 55% higher cell binding potential of WGA-grafted particles than those without a targeter, targeted protein nanocapsules represent the first step towards new and innovative formulations.
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