Prevalence of serological markers of hepatitis B in inflammatory bowel disease - Experience from a tertiary care centre in South India

Inflammatory bowel disease patients are at risk of hepatitis B infection. Data on this prevalence from South Asia are limited. We conducted a prospective study comprising of 76 inflammatory bowel disease patients between October 2013 and August 2014. Prevalence of hepatitis B surface antigen in inflammatory bowel disease, ulcerative colitis and Crohn's disease patients were 2.6%, 2.4% and 3% respectively and that of markers of hepatitis B exposure (hepatitis B surface antigen /hepatitis B core antibody) were 11.8%, 14.3% and 9.1% respectively. Risk factors found significantly more common in those positive for viral markers compared to those negative were age, non-inflammatory bowel disease related surgery and hospital admission. Only 7(9.2%) had completed hepatitis B vaccination. There is a need to create awareness among physicians regarding the importance of hepatitis B screening and vaccination in inflammatory bowel disease patients.

Automated summary

Patients with inflammatory bowel disease are at risk of hepatitis B infection. There is a need to raise awareness among physicians regarding the importance of screening and vaccination for hepatitis B in these patients. Risk factors for positive viral markers include age, non-inflammatory bowel disease-related surgery, and hospital admission.