期刊
TRENDS IN PHARMACOLOGICAL SCIENCES
卷 42, 期 11, 页码 897-911出版社
CELL PRESS
DOI: 10.1016/j.tips.2021.08.002
关键词
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资金
- Indonesia Endowment Fund for Education
- UKRI Future Leaders Fellowship [MR/T04327X/1]
- UK Dementia Research Institute from UK DRI Ltd
- UK Medical Research Council
- Alzheimer's Society
- Alzheimer's Research UK
- Rosetrees, UK Medical Research Council
The article discusses the role of histone post-translational modifications (PTMs) in influencing nociception and pain phenotypes following tissue injury, and the opportunities and challenges of targeting histone PTMs to relieve pain in clinically relevant tissue injuries.
Effective pharmacological management of pain associated with tissue pathology is an unmet medical need. Transcriptional modifications in nociceptive pathways are pivotal for the development and the maintenance of pain associated with tissue damage. Accumulating evidence has shown the importance of the epigenetic control of transcription in nociceptive pathways via histone post-translational modifications (PTMs). Hence, histone PTMs could be targets for novel effective analgesics. Here, we discuss the current understanding of histone PTMs in the modulation of gene expression affecting nociception and pain phenotypes following tissue injury. We also provide a critical view of the translational implications of preclinical models and discuss opportunities and challenges of targeting histone PTMs to relieve pain in clinically relevant tissue injuries.
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