期刊
TRENDS IN MOLECULAR MEDICINE
卷 27, 期 9, 页码 895-906出版社
CELL PRESS
DOI: 10.1016/j.molmed.2021.06.002
关键词
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资金
- US Public Health Service grant [5U54AI138370]
SARS-CoV-2 infection can lead to chronic and acute diseases, with postacute sequelae including potential organ damage and symptoms, as well as a post-COVID19 syndrome called 'long COVID' resembling ME/CFS symptoms.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause chronic and acute disease. Postacute sequelae of SARS-CoV-2 infection (PASC) include injury to the lungs, heart, kidneys, and brain that may produce a variety of symptoms. PASC also includes a post-coronavirus disease 2019 (COVID-19) syndrome ('long COVID') with features that can follow other acute infectious diseases and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Here we summarize what is known about the pathogenesis of ME/CFS and of 'acute' COVID-19, and we speculate that the pathogenesis of post-COVID19 syndrome in some people may be similar to that of ME/CFS. We propose molecular mechanisms that might explain the fatigue and related symptoms in both illnesses, and we suggest a research agenda for both ME/CFS and post- COVID-19 syndrome.
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