Impact of the Natural Compound Urolithin A on Health, Disease, and Aging

Urolithin A (UA) is a natural compound produced by gut bacteria from ingested ellagitannins (ETs) and ellagic acid (EA), complex polyphenols abundant in foods such as pomegranate, berries, and nuts. UA was discovered 40 years ago, but only recently has its impact on aging and disease been explored. UA enhances cellular health by increasing mitophagy and mitochondrial function and reducing detrimental inflammation. Several preclinical studies show how UA protects against aging and age-related conditions affecting muscle, brain, joints, and other organs. In humans, benefits of UA supplementation in the muscle are supported by recent clinical trials in elderly people. Here, we review the state of the art of UA's biology and its translational potential as a nutritional intervention in humans.

Automated summary

Urolithin A is a natural compound derived from gut bacteria, with benefits such as enhancing cellular health and reducing inflammation. Preclinical studies have shown that UA plays a crucial role in protecting muscles, brain, joints, and other organs from aging and age-related conditions.