Extracellular matrix-based cancer targeting

Tumor extracellular matrix (ECM) operates in a coordinated mode with cancer and stroma cells to evoke the multistep process of metastatic potential. The remodeled tumor-associated matrix provides a point for direct or complemen-tary therapeutic targeting. Here, we cover and critically address the importance of ECM networks and their macromolecules in cancer. We focus on the roles of key structural and functional ECM components, and their degradation enzymes and extracellular vesicles, aiming at improving our understanding of the mecha-nisms contributing to tumor initiation, growth, and dissemination, and discuss potential new approaches for ECM-based therapeutic targeting and diagnosis.

Automated summary

Tumor extracellular matrix collaborates with cancer and stroma cells to facilitate the multistep process of metastasis, highlighting the importance of ECM networks in cancer therapeutics and diagnostics.