期刊
TRENDS IN MOLECULAR MEDICINE
卷 27, 期 9, 页码 839-843出版社
CELL PRESS
DOI: 10.1016/j.molmed.2021.06.006
关键词
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资金
- National Natural Science Foundation of China [81874253, 81830097]
- Excellent postdoctoral innovative talents of Hunan province in 2020 [2020RC2014]
- Non-Profit Central Research Institute Fund of the Chinese Academy of Medical Sciences [2020-RC320-003]
- innovation project of the Chinese Academy of Medical Sciences (Research Unit) [2019-I2M-5-0 33]
Lupus erythematosus (LE) is a highly heterogeneous disease that occurs when a genetically susceptible individual encounters specific environmental triggers. Epigenetics plays a crucial role in understanding the interactions between genetics and environment, which could contribute to precision prevention and treatment of lupus by comprehensively exploring the hidden mysteries behind the genome, epigenome, and exposome.
As an extremely heterogeneous disease, lupus erythematosus (LE) occurs when a genetically susceptible individual encounters specific environmental triggers. Epigenetics bridges genetics and environment and helps explain their interactions. Comprehensively understanding the hidden mysteries behind the genome, epigenome, and exposome of lupus could contribute to precision prevention and treatment of lupus.
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