Runner's niche: multipurpose stromal cells maintained by exercise

Using newly developed reporter and lineage-tracing mice, Shen et al. found perivascular stromal cells coexpressing osteolectin and leptin receptor in the bone marrow that specifically supported lymphoid progenitors, served as osteoblast progenitors, and were maintained by mechanical stimulation. Exercise may thus have joint positive influences on lymphopoiesis and bone formation.

Automated summary

The study identified perivascular stromal cells in the bone marrow that coexpress osteolectin and leptin receptor and play important roles in supporting lymphoid progenitors and serving as osteoblast progenitors, while being maintained by mechanical stimulation. This suggests that exercise may have positive effects on lymphopoiesis and bone formation by targeting these specific cell populations.