期刊
TRENDS IN IMMUNOLOGY
卷 42, 期 8, 页码 658-669出版社
CELL PRESS
DOI: 10.1016/j.it.2021.06.003
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资金
- FAST Grant, George Mason Mercatus Center
- Biotechnology and Biological Sciences Research Council [BBS/E/B/000C0427, BBS/E/B/000C0428]
- Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) [BA 5132/1-2 (252623821), EXC2151 (390873048)]
- Region Occitanie [19011 75]
- European Regional Development Fund [MP0022856]
- Ministry of Health of the NSW government of Australia [GNT1138359]
- NHMRC of Australia [GNT1138359]
- NHMRC [1176665, 1113904]
- [R01AI136942]
- [P01 HL132819]
- [R37 AR40072]
- [R01 AR074545]
- [INCA-12642]
- [ANR-16-CE15-0019-02]
- [ANR-16-CE15-0002-02]
- National Health and Medical Research Council of Australia [1113904, 1176665] Funding Source: NHMRC
Tfh and Tfh-like cells guide B cell differentiation in secondary lymphoid tissues, playing essential roles in humoral immunity. They produce diverse combinations of cytokines and chemokine receptors to promote the generation of antibodies with different properties.
T follicular helper (Tfh) cells cognately guide differentiation of antigen-primed B cells in secondary lymphoid tissues. 'Tfh-like' populations not expressing the canonical Tfh cell transcription factor BCL6 have also been described, which can aid particular aspects of B cell differentiation. Tfh and Tfh-like cells are essential for protective and pathological humoral immunity. These CD4+ T cells that help B cells are polarized to produce diverse combinations of cytokines and chemokine receptors and can be grouped into distinct subsets that promote antibodies of different isotype, affinity, and duration, according to the nature of immune challenge. However, unified nomenclature to describe the distinct functional Tfh and Tfh-like cells does not exist. While explicitly acknowledging cellular plasticity, we propose categorizing these cell states into three groups based on phenotype and function, paired with their anatomical site of action.
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