期刊
TRENDS IN IMMUNOLOGY
卷 42, 期 8, 页码 706-722出版社
CELL PRESS
DOI: 10.1016/j.it.2021.06.004
关键词
-
类别
资金
- Kennedy Trust for Rheumatology Research [KENN151607]
- BBSRC [BB/R015651/1]
- Cancer Research UK [C65275/A29549]
- Arthritis Research UK [19652, 20525]
- Royal Society
- Wellcome Trust [086054]
- Israel Science Foundation [791/17]
- Minerva Foundation
- ERA-Net ERare3
- GIF [I1470412.13/2018]
- Division of Intramural Research of the National Heart, Lung, and Blood Institute, NIH
- Academy of Medical Sciences Springboard award [SBF006\1100]
- BBSRC [BB/R015651/1] Funding Source: UKRI
The integrin LFA-1 plays a crucial role in T cell entry into lymph nodes and tissues, interactions with antigen-presenting cells, as well as additional functions such as T-T communication and support of T cell memory. Understanding the biology of LFA-1 and its mechanobiology is important for studying immunological synapses and pathologies related to LFA-1 dysregulation.
The integrin LFA-1 is crucial for T cell entry into mammalian lymph nodes and tissues, and for promoting interactions with antigen-presenting cells (APCs). However, it is increasingly evident that LFA-1 has additional key roles beyond the mere support of adhesion between T cells, the endothelium, and/or APCs. These include roles in homotypic T cell-T cell (T-T) communication, the induction of intracellular complement activity underlying Th1 effector cell polarization, and the support of long-lasting T cell memory. Here, we briefly summarize current knowledge of LFA-1 biology, discuss novel cytoskeletal regulators of LFA-1 functions, and review new aspects of LFA-1 mechanobiology that are relevant to its function in immunological synapses and in specific pathologies arising from LFA-1 dysregulation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据