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MicroRNAs, damage levels, and DNA damage response control

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TRENDS IN GENETICS
卷 37, 期 11, 页码 963-965

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CELL PRESS
DOI: 10.1016/j.tig.2021.06.018

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DNA damage-induced miRNAs are important in the DNA damage response, influencing cell fate. However, it is still unclear who is in charge in this process.
DNA damage-inducible miRNAs are likely to be functional in the DNA damage response. This response can elicit damage resolution and cell survival or apoptosis. The current, albeit incomplete, picture suggests that miRNAs can affect cell fate via modulation of key response proteins, but the question is, who's in charge?

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