期刊
TRENDS IN GENETICS
卷 37, 期 12, 页码 1095-1108出版社
CELL PRESS
DOI: 10.1016/j.tig.2021.06.008
关键词
-
资金
- Czech Science Foundation [20-04075S]
Hybrid sterility is a critical step in the evolution of reproductive barriers between diverging taxa, controlled by chromosomal sequence divergence. Prdm9-dependent hybrid sterility affects meiotic recombination, serving as a possible mechanism of reproductive isolation between (sub)species.
Hybrid sterility is a critical step in the evolution of reproductive barriers between diverging taxa during the process of speciation. Recent studies of young subspecies of the house mouse revealed a multigenic nature and frequent polymorphism of hybrid sterility genes as well as the recurrent engagement of the meiosis-specific gene PR domain-containing 9 (Prdm9) and X-linked loci. Prdm9-controlled hybrid sterility is essentially chromosomal in nature, conditioned by the sequence divergence between subspecies. Depending on the Prdm9 interallelic interactions and the X-linked Hstx2 locus, the same homologs either regularly recombine and synapse, or show impaired DNA DSB repair, asynapsis, and early meiotic arrest. Thus, Prdm9-dependent hybrid sterility points to incompatibilities affecting meiotic recombination as a possible mechanism of reproductive isolation between (sub)species.
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