The study by Ioannidis and colleagues highlights the role of the DMRT1 gene as the master regulator of testis development in chickens. Surprisingly, when this gene is deleted in genetic males leading to ovary formation, the body still maintains male characteristics, challenging the previous belief that somatic sex in birds is primarily hormone-driven.
Ioannidis and colleagues show that the gene DMRT1 is the master regulator of testis development in the chicken. Yet, remarkably, when this gene is deleted in genetic males and gonads form ovaries, the body remains male. This debunks the notion that somatic sex is driven primarily by hormones in birds.
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