FKBP51 and the molecular chaperoning of metabolism

The molecular chaperone FK506-binding protein 51 (FKBP51) is gaining attention as a meaningful biomarker of metabolic dysfunction. This review examines the emerging contributions of FKBP51 in adipogenesis and lipid metabolism, myogenesis and protein catabolism, and glucocorticoid-induced skin hypoplasia and dermal adipocytes. The FKBP51 signaling mechanisms that may explain these metabolic consequences are discussed. These mechanisms are diverse, with FKBP51 independently and directly regulating phosphorylation cascades and nuclear receptors. We provide a discussion of the newly developed compounds that antagonize FKBP51, which may offer therapeutic advantages for adiposity. These observations suggest we are only beginning to uncover the complex nature of FKBP51 and its molecular chaperoning of metabolism.

Automated summary

FK506-binding protein 51 (FKBP51) is becoming recognized as a significant biomarker of metabolic dysfunction, with diverse regulatory roles in lipid metabolism, protein catabolism, and dermal adipocytes. The signaling mechanisms of FKBP51 and potential therapeutic compounds targeting it are currently being explored.