期刊
TRENDS IN BIOTECHNOLOGY
卷 40, 期 2, 页码 240-254出版社
CELL PRESS
DOI: 10.1016/j.tibtech.2021.06.008
关键词
-
资金
- National Research Foundation of the Ministry of Science and ICT [2018R1A5A1025077, 2021R1A2C1006436]
- Strategic Initiative for Microbiomes in the Ministry of Agriculture, Food, and Rural Affairs (as part of the multi-ministerial) Genome Technology to Business Translation Program, Republic of Korea
- National Research Foundation of Korea [2021R1A2C1006436] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
This article discusses the recent efforts and technologies used for discovering and mining enzymes from the human gut microbiota. The wealth of knowledge on metabolites, reactions, genome sequences, and protein structures may lead to the development of strategies for enzyme mining. Ongoing efforts to annotate gut microbiota enzymes may elucidate catalytic mechanisms that could guide the clinical applications of the gut microbiome for diagnostic and therapeutic purposes.
Advances in technological and bioinformatics approaches have led to the generation of a plethora of human gut metagenomic datasets. Metabolomics has also provided substantial data regarding the small metabolites produced and modified by the microbiota. Comparatively, the microbial enzymes mediating the transformation of metabolites have not been intensively investigated. Here, we discuss the recent efforts and technologies used for discovering and mining enzymes from the human gut microbiota. The wealth of knowledge on metabolites, reactions, genome sequences, and structures of proteins, may drive the development of strategies for enzyme mining. Ongoing efforts to annotate gut microbiota enzymes will explain catalytic mechanisms that may guide the clinical applications of the gut microbiome for diagnostic and therapeutic purposes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据