4.6 Review

Chemical genetic methodologies for identifying protein substrates of PARPs

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biology

Identification of PARP-7 substrates reveals a role for MARylation in microtubule control in ovarian cancer cells

Lavanya H. Palavalli Parsons et al.

Summary: PARP-7, a mono(ADP-ribosyl) transferase, plays a role in ovarian cancer cells by influencing cell growth and migration. Through MARylation of alpha-tubulin, it promotes microtubule instability to regulate cell growth and motility, with implications in cancer-related cellular phenotypes.
Article Biology

Chemical genetics and proteome-wide site mapping reveal cysteine MARylation by PARP-7 on immune-relevant protein targets

Kelsie M. Rodriguez et al.

Summary: PARP-7 has been identified as an important regulator of the innate immune response, with a key target being the inactive PARP family member PARP-13. Specifically, PARP-7 preferentially MARylates cysteine residues in the RNA binding zinc finger domain of PARP-13, as revealed by proteome-wide ADP-ribosylation analysis.
Article Multidisciplinary Sciences

System-wide identification and prioritization of enzyme substrates by thermal analysis

Amir Ata Saei et al.

Summary: The SIESTA method is a high-throughput unbiased proteomics approach for identifying and prioritizing enzyme-modified substrate proteins based on changes in thermal stability. In proof-of-concept studies, it successfully identified known and novel substrate candidates for several enzyme systems. This method provides a potential tool for better understanding enzyme functions and could aid in drug discovery.

NATURE COMMUNICATIONS (2021)

Article Multidisciplinary Sciences

Single-cell analysis of human ovarian cortex identifies distinct cell populations but no oogonial stem cells

Magdalena Wagner et al.

NATURE COMMUNICATIONS (2020)

Article Biochemistry & Molecular Biology

Bump-and-Hole Engineering Identifies Specific Substrates of Glycosyltransferases in Living Cells

Benjamin Schumann et al.

MOLECULAR CELL (2020)

Article Biochemistry & Molecular Biology

A single-cell landscape of high-grade serous ovarian cancer

Benjamin Izar et al.

NATURE MEDICINE (2020)

Article Virology

Characterization of Novel Splice Variants of Zinc Finger Antiviral Protein (ZAP)

Melody M. H. Li et al.

JOURNAL OF VIROLOGY (2019)

Article Chemistry, Multidisciplinary

Engineering Orthogonal Polypeptide GalNAc-Transferase and UDP-Sugar Pairs

Junwon Choi et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

Article Immunology

PARP14 Controls the Nuclear Accumulation of a Subset of Type I IFN-Inducible Proteins

Greta Caprara et al.

JOURNAL OF IMMUNOLOGY (2018)

Article Biochemistry & Molecular Biology

A Potent and Selective PARP11 Inhibitor Suggests Coupling between Cellular Localization and Catalytic Activity

Ilsa T. Kirby et al.

CELL CHEMICAL BIOLOGY (2018)

Review Cell Biology

The nuclear pore complex: understanding its function through structural insight

Martin Beck et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2017)

Article Biochemistry & Molecular Biology

Chemical proteomics reveals ADP-ribosylation of small GTPases during oxidative stress

Nathan P. Westcott et al.

NATURE CHEMICAL BIOLOGY (2017)

Article Biochemistry & Molecular Biology

The role of poly ADP-ribosylation in the first wave of DNA damage response

Chao Liu et al.

NUCLEIC ACIDS RESEARCH (2017)

Article Multidisciplinary Sciences

Mitochondrial damage elicits a TCDD-inducible poly(ADP-ribose) polymerase- mediated antiviral response

Tatsuya Kozaki et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Multidisciplinary Sciences

PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation

Hiroshi Iwata et al.

NATURE COMMUNICATIONS (2016)

Article Reproductive Biology

Spermatid Head Elongation with Normal Nuclear Shaping Requires ADP-Ribosyltransferase PARP11 (ARTD11) in Mice

Mirella L. Meyer-Ficca et al.

BIOLOGY OF REPRODUCTION (2015)

Article Cell Biology

P-body assembly requires DDX6 repression complexes rather than decay or Ataxin2/2L complexes

Jessica Ayache et al.

MOLECULAR BIOLOGY OF THE CELL (2015)

Article Genetics & Heredity

Distribution of protein poly(ADP-ribosyl)ation systems across all domains of life

Dragutin Perina et al.

DNA REPAIR (2014)

Article Biochemistry & Molecular Biology

The ADP-ribosyltransferase PARP10/ARTD10 Interacts with Proliferating Cell Nuclear Antigen ( PCNA) and Is Required for DNA Damage Tolerance

Claudia M. Nicolae et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Article Chemistry, Multidisciplinary

Engineering the Substrate Specificity of ADP-Ribosyltransferases for Identifying Direct Protein Targets

Ian Carter-O'Connell et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)

Article Biochemistry & Molecular Biology

ARTD2 activity is stimulated by RNA

Karolin Leger et al.

NUCLEIC ACIDS RESEARCH (2014)

Review Biochemistry & Molecular Biology

Transcription elongation factors DSIF and NELF: Promoter-proximal pausing and beyond

Yuki Yamaguchi et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS (2013)

Article Cell Biology

ARTD10 substrate identification on protein microarrays: regulation of GSK3β by mono-ADP-ribosylation

Karla L. H. Feijs et al.

CELL COMMUNICATION AND SIGNALING (2013)

Review Biochemistry & Molecular Biology

Post-Transcriptional Regulation by Poly(ADP-ribosyl)ation of the RNA-Binding Proteins

Yingbiao Ji et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2013)

Review Biochemistry & Molecular Biology

PARP-1 and gene regulation: Progress and puzzles

W. Lee Kraus et al.

MOLECULAR ASPECTS OF MEDICINE (2013)

Article Multidisciplinary Sciences

Regulation of NF-κB signalling by the mono-ADP-ribosyltransferase ARTD10

Patricia Verheugd et al.

NATURE COMMUNICATIONS (2013)

Article Multidisciplinary Sciences

A systematic analysis of the PARP protein family identifies new functions critical for cell physiology

Sejal Vyas et al.

NATURE COMMUNICATIONS (2013)

Article Biochemistry & Molecular Biology

PARP-14 Functions as a Transcriptional Switch for Stat6-dependent Gene Activation

Purvi Mehrotra et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Chemistry, Multidisciplinary

Labeling Substrates of Protein Arginine Methyltransferase with Engineered Enzymes and Matched S-Adenosyl-L-methionine Analogues

Rui Wang et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)

Article Biochemical Research Methods

Investigation of PARP-1, PARP-2, and PARG interactomes by affinity-purification mass spectrometry

Maxim Isabelle et al.

PROTEOME SCIENCE (2010)

Article Biochemistry & Molecular Biology

Poly(ADP-ribosyl)ation of heterogeneous nuclear ribonucleoproteins modulates splicing

Yingbiao Ji et al.

NUCLEIC ACIDS RESEARCH (2009)

Article Multidisciplinary Sciences

p72 DEAD box RNA helicase is required for optimal function of the zinc-finger antiviral protein

Guifang Chen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Biochemistry & Molecular Biology

Collaborator of stat6 (CoaSt6)-associated poly(ADP-ribose) polymerase activity modulates stat6-dependent gene transcription

Shreevrat Goenka et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)