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From ARDS to pulmonary fibrosis: the next phase of the COVID-19 pandemic?

TRANSLATIONAL RESEARCH (2022)

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Article Pathology

Fatal pulmonary fibrosis: a post-COVID-19 autopsy case

Hanna Ferlov Schwensen et al.

Summary: A Caucasian female in her 80s who died from severe pulmonary fibrosis after eliminating SARS-CoV-2 infection underwent autopsy, revealing widespread fibrosis in previously healthy lungs. The microscopic examination showed acute and organizing diffuse alveolar damage and fibrosis with honeycomb-like remodelling and bronchial metaplasia.

JOURNAL OF CLINICAL PATHOLOGY (2021)

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Review Pathology

Mechanical Feed-Forward Loops Contribute to Idiopathic Pulmonary Fibrosis

Margaret A. T. Freeberg et al.

Summary: Idiopathic pulmonary fibrosis is a progressive disease characterized by accumulation of extracellular matrix in lung tissue, leading to altered mechanical properties. Recent studies suggest that these changes create a feed-forward loop, contributing to fibroblast differentiation and activation. Mechanotransduction pathways, including mechanosensors like integrins and downstream transcription factors, play a role in fibrosis progression.

AMERICAN JOURNAL OF PATHOLOGY (2021)

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Article Critical Care Medicine

Senescence of Alveolar Type 2 Cells Drives Progressive Pulmonary Fibrosis

Changfu Yao et al.

Summary: The study demonstrates that senescence of AT2 cells is sufficient to drive progressive pulmonary fibrosis, and interventions targeting p53 activation or senescence can block fibrogenesis. Early attenuation of senescence-related pathways and elimination of senescent cells are promising therapeutic approaches to prevent pulmonary fibrosis.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2021)

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Review Physiology

Healing after COVID-19: are survivors at risk for pulmonary fibrosis?

Lindsay T. McDonald

Summary: The novel SARS-CoV-2 coronavirus, responsible for COVID-19, was first reported in Wuhan, China, in December 2019, and the World Health Organization declared a pandemic by March 2020. Concerns have been raised about potential long-term effects of COVID-19 on respiratory health, but with limited data available, predictions on long-term outcomes remain speculative. Improved recognition of potential risk factors for fibrotic disease through studying previous coronavirus outbreaks is crucial in understanding the potential long-term implications of COVID-19.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2021)

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Review Biochemistry & Molecular Biology

Adaptive immunity to SARS-CoV-2 and COVID-19

Alessandro Sette et al.

Summary: The adaptive immune system, consisting of B cells, CD4(+) T cells, and CD8(+) T cells, plays varying roles in different viral infections and vaccines. Studies are showing that CD4(+) T cells, CD8(+) T cells, and neutralizing antibodies all play a part in controlling SARS-CoV-2 in COVID-19 cases, emphasizing the importance of understanding adaptive immunity in combating the disease.

CELL (2021)

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Article Respiratory System

Pulmonary function and radiological features 4 months after COVID-19: first results from the national prospective observational Swiss COVID-19 lung study

Sabina A. Guler et al.

Summary: The Swiss COVID-19 lung study investigated pulmonary sequelae of COVID-19 in 113 survivors. Severe/critical COVID-19 was associated with significant functional and radiological abnormalities 4 months after infection, potentially due to small-airway and lung parenchymal disease. Systematic follow-up for survivors needs to be evaluated to optimize care for patients recovering from COVID-19.

EUROPEAN RESPIRATORY JOURNAL (2021)

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Article Cell Biology

Molecular markers of telomere dysfunction and senescence are common findings in the usual interstitial pneumonia pattern of lung fibrosis

Joyce S. Lee et al.

Summary: The study found that molecular markers of telomere dysfunction and senescence are pathologically expressed in both IPF and non-IPF UIP lungs, suggesting that common molecular drivers may contribute to the pathogenesis of UIP-associated pulmonary fibrosis, regardless of the clinical diagnosis.

HISTOPATHOLOGY (2021)

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Article Medicine, General & Internal

6-month consequences of COVID-19 in patients discharged from hospital: a cohort study (Publication with Expression of Concern. See vol. 401, pg. 90, 2023)

Chaolin Huang et al.

Summary: This study aimed to investigate the long-term health consequences of discharged COVID-19 patients and associated risk factors, particularly disease severity. Patients with more severe illness during hospitalization showed more severe impaired pulmonary diffusion capacities and abnormal chest imaging manifestations, highlighting the need for targeted interventions for long-term recovery.

LANCET (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Six-month Follow-up Chest CT Findings after Severe COVID-19 Pneumonia

Xiaoyu Han et al.

Summary: The study found that over one-third of severe COVID-19 patients showed fibrotic-like changes in the lung at 6-month follow-up CT, which were associated with older age, acute respiratory distress syndrome, longer hospital stays, tachycardia, noninvasive mechanical ventilation, and higher initial chest CT score.

RADIOLOGY (2021)

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Review Virology

Biological and Clinical Consequences of Integrin Binding via a Rogue RGD Motif in the SARS CoV-2 Spike Protein

Lee Makowski et al.

Summary: This paper proposes the hypothesis that viral binding to cell-surface integrins may contribute to the high infectivity and widespread extra-pulmonary impacts of SARS-CoV-2. The emergence of an RGD sequence in the receptor-binding domain of the spike protein is suggested to be potentially responsible for this. The interactions between virions and integrins could dysregulate signaling pathways and lead to tissue damage, with implications for various clinical outcomes.

VIRUSES-BASEL (2021)

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Letter Medicine, General & Internal

Association of Smoking and Cumulative Pack-Year Exposure With COVID-19 Outcomes in the Cleveland Clinic COVID-19 Registry

Katherine E. Lowe et al.

JAMA INTERNAL MEDICINE (2021)

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Article Medicine, General & Internal

Respiratory and Psychophysical Sequelae Among Patients With COVID-19 Four Months After Hospital Discharge

Mattia Bellan et al.

Summary: The study examined the prevalence of lung function, exercise function, and psychological sequelae among survivors of severe COVID-19 four months after discharge. Over half of patients experienced reduced lung capacity, one-fifth had functional impairment, and about one-fifth showed symptoms of posttraumatic stress. These findings suggest that a significant proportion of COVID-19 survivors may continue to experience respiratory, functional, or psychological issues months after hospital discharge.

JAMA NETWORK OPEN (2021)

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Review Biochemistry & Molecular Biology

COVID-19 and the human innate immune system

Joachim L. Schultze et al.

Summary: The introduction of SARS-CoV-2 into the human population has led to a significant medical and economic crisis. Innate immunity plays a central role in combating the novel virus, with variability in its components contributing to the diverse disease courses observed for COVID-19. Further research into the pathophysiological mechanisms of innate immunity is crucial for the development of diagnostic markers and therapeutic strategies targeting COVID-19.

CELL (2021)

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Article Medicine, General & Internal

Shared genetic etiology between idiopathic pulmonary fibrosis and COVID-19 severity

Joao Fadista et al.

Summary: There is a positive genetic correlation between IPF and COVID-19 severity, but the causal relationship between IPF and COVID-19 severity is not clear. However, one specific IPF risk gene shows a causal effect on COVID-19 severity, while another IPF risk gene appears to have a protective effect against COVID-19 hospitalization in older adults.

EBIOMEDICINE (2021)

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Letter Medicine, General & Internal

Sequelae in Adults at 6 Months After COVID-19 Infection

Jennifer K. Logue et al.

JAMA NETWORK OPEN (2021)

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Letter Medicine, General & Internal

Sixty-Day Outcomes Among Patients Hospitalized With COVID-19

Vineet Chopra et al.

ANNALS OF INTERNAL MEDICINE (2021)

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Article Multidisciplinary Sciences

The spatial landscape of lung pathology during COVID-19 progression

Andre F. Rendeiro et al.

Summary: Recent studies using high-parameter imaging mass cytometry have provided insights into the cellular composition and spatial architecture of acute lung injury in humans, including injuries derived from SARS-CoV-2 infection. It was found that SARS-CoV-2 predominantly infects alveolar epithelial cells and induces a localized hyperinflammatory cell state associated with lung damage. As COVID-19 progresses, there is increased macrophage extravasation, along with increased numbers of mesenchymal cells and fibroblasts, possibly indicating attempts to repair the damaged lung tissue. The data generated help in developing a biologically interpretable landscape of lung pathology at both macroscopic and single-cell levels, providing a basis for understanding COVID-19 and lung pathology.

NATURE (2021)

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Review Biochemistry & Molecular Biology

Post-acute COVID-19 syndrome

Ani Nalbandian et al.

Summary: SARS-CoV-2 is responsible for the COVID-19 pandemic, causing global healthcare crises. Recovery from COVID-19 may lead to persistent symptoms and long-term complications, prompting the need for multidisciplinary care and follow-up for survivors.

NATURE MEDICINE (2021)

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Article Respiratory System

Pulmonary fibrosis 4 months after COVID-19 is associated with severity of illness and blood leucocyte telomere length

Claire F. McGroder et al.

Summary: Patients who underwent mechanical ventilation for severe COVID-19 are more likely to develop fibrotic-like radiographic abnormalities after hospitalisation. The severity of initial illness, duration of mechanical ventilation, lactate dehydrogenase on admission, and leucocyte telomere length are independent risk factors for these abnormalities, which are correlated with lung function, cough, and frailty measures, but not with dyspnoea.

THORAX (2021)

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Article Critical Care Medicine

3-month, 6-month, 9-month, and 12-month respiratory outcomes in patients following COVID-19-related hospitalisation: a prospective study

Xiaojun Wu et al.

Summary: Most patients recovering from severe COVID-19 showed improvement in dyspnoea scores and exercise capacity over time, but a subgroup of patients still exhibited persistent physiological and radiographic changes at 12 months post-discharge. A unified pathway for respiratory follow-up is needed for COVID-19 patients.

LANCET RESPIRATORY MEDICINE (2021)

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Article Hematology

Tissue factor upregulation is associated with SARS-CoV-2 in the lungs of COVID-19 patients

Sandeep Subrahmanian et al.

Summary: The upregulation of tissue factor (TF) expression in the lungs of COVID-19 patients may be associated with thrombus formation, which could serve as a key therapeutic target. The correlation of TF expression with SARS-CoV-2 in COVID-19 lungs raises the possibility of direct TF induction by the virus.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2021)

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Review Medicine, General & Internal

Acute respiratory distress syndrome

Nuala J. Meyer et al.

Summary: This article summarizes the epidemiology, diagnosis, and treatment of acute respiratory distress syndrome (ARDS), while also discussing the similarities and differences between ARDS caused by COVID-19 and ARDS caused by other factors.

LANCET (2021)

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Article Multidisciplinary Sciences

Pulmonary fibrosis distal airway epithelia are dynamically and structurally dysfunctional

Ian T. Stancil et al.

Summary: Environmental and genetic risk factors affect the distal airway epithelium in idiopathic pulmonary fibrosis (IPF), but the specific role of the epithelium in the disease remains unclear. The study demonstrates that pathologic activation of the ERBB-YAP axis induces dysfunction in distal airway epithelium, leading to a pro-fibrotic phenotype in mesenchymal cells.

NATURE COMMUNICATIONS (2021)

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Review Medicine, Research & Experimental

Distinctive features of severe SARS-CoV-2 pneumonia

G. R. Scott Budinger et al.

Summary: The COVID-19 pandemic is a major public health crisis of our generation, with severe patients expected to continue filling hospitals and intensive care units. While there are similarities in the clinical presentation and pathobiology of ARDS between pneumonia caused by SARS-CoV-2 and other respiratory pathogens, there are also unique features that could be targeted for therapeutics.

JOURNAL OF CLINICAL INVESTIGATION (2021)

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Article Respiratory System

Persistent Post-COVID-19 Interstitial Lung Disease An Observational Study of Corticosteroid Treatment

Katherine Jane Myall et al.

Summary: Following SARS-CoV-2 infection, some patients develop persistent radiological inflammatory lung disease and functional deficits. Early treatment with corticosteroids is well tolerated and associated with rapid and significant improvement.

ANNALS OF THE AMERICAN THORACIC SOCIETY (2021)

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Article Critical Care Medicine

Static compliance of the respiratory system in COVID-19 related ARDS: an international multicenter study

Benoit Vandenbunder et al.

Summary: In COVID-19-related ARDS, Crs does not seem to have a significant impact on patient outcomes, while plateau pressure may be associated with the chance of breathing independently. In some patients, a decrease in Crs between day 1 and day 14 is observed, but this change does not affect the outcome on day 28.

CRITICAL CARE (2021)

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Article Critical Care Medicine

Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis

Richard J. Allen et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2020)

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Article Critical Care Medicine

Recommended Reading from the University of Michigan Pulmonary and Critical Care Fellowship Program

Leigh M Cagino et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2020)

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Review Biochemistry & Molecular Biology

Regulated Necrosis in Pulmonary Disease A Focus on Necroptosis and Ferroptosis

Shunsuke Minagawa et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2020)

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Article Biochemistry & Molecular Biology

Progressive Pulmonary Fibrosis Is Caused by Elevated Mechanical Tension on Alveolar Stem Cells

Huijuan Wu et al.

CELL (2020)

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Editorial Material Medicine, General & Internal

Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention

Zunyou Wu et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

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Article Medicine, General & Internal

Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China

Dawei Wang et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

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Article Medicine, General & Internal

Clinical Characteristics of Coronavirus Disease 2019 in China

W. Guan et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Review Hematology

Hematological findings and complications of COVID-19

Evangelos Terpos et al.

AMERICAN JOURNAL OF HEMATOLOGY (2020)

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Letter Critical Care Medicine

COVID-19 Does Not Lead to a Typical Acute Respiratory Distress Syndrome

Luciano Gattinoni et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2020)

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Article Pharmacology & Pharmacy

A potential role for integrins in host cell entry by SARS-CoV-2

Christian J. A. Sigrist et al.

ANTIVIRAL RESEARCH (2020)

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Review Cell & Tissue Engineering

The Cellular and Physiological Basis for Lung Repair and Regeneration: Past, Present, and Future

Maria C. Basil et al.

CELL STEM CELL (2020)

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Article Cardiac & Cardiovascular Systems

COVID-19 and Cardiovascular Disease

Kevin J. Clerkin et al.

CIRCULATION (2020)

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Letter Immunology

Obesity in Patients Younger Than 60 Years Is a Risk Factor for COVID-19 Hospital Admission

Jennifer Lighter et al.

CLINICAL INFECTIOUS DISEASES (2020)

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Article Respiratory System

Vascular permeability in the fibrotic lung

Clemens K. Probst et al.

EUROPEAN RESPIRATORY JOURNAL (2020)

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Editorial Material Respiratory System

Abnormal pulmonary function in COVID-19 patients at time of hospital discharge

Xiaoneng Mo et al.

EUROPEAN RESPIRATORY JOURNAL (2020)

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Article Gastroenterology & Hepatology

Prevalence and Characteristics of Gastrointestinal Symptoms in Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection in the United States: A Multicenter Cohort Study

Walker D. Redd et al.

GASTROENTEROLOGY (2020)

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Article Critical Care Medicine

Small airways pathology in idiopathic pulmonary fibrosis: a retrospective cohort study

Stijn E. Verleden et al.

LANCET RESPIRATORY MEDICINE (2020)

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Editorial Material Critical Care Medicine

COVID-19 pneumonia: different respiratory treatments for different phenotypes?

Luciano Gattinoni et al.

INTENSIVE CARE MEDICINE (2020)

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Editorial Material Medicine, General & Internal

Management of COVID-19 Respiratory Distress

John J. Marini et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

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Letter Infectious Diseases

A potential inhibitory role for integrin in the receptor targeting of SARS-CoV-2

Junwen Luan et al.

JOURNAL OF INFECTION (2020)

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Article Medical Laboratory Technology

Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: A report of five cases

Cynthia Magro et al.

TRANSLATIONAL RESEARCH (2020)

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Article Medicine, General & Internal

Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China

Chaomin Wu et al.

JAMA INTERNAL MEDICINE (2020)

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Article Clinical Neurology

Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China

Ling Mao et al.

JAMA NEUROLOGY (2020)

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Letter Medicine, General & Internal

Endothelial cell infection and endotheliitis in COVID-19

Zsuzsanna Varga et al.

LANCET (2020)

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Article Medicine, General & Internal

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

Fei Zhou et al.

LANCET (2020)

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Article Critical Care Medicine

Pulmonary fibrosis secondary to COVID-19: a call to arms?

Paolo Spagnolo et al.

Lancet Respiratory Medicine (2020)

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Article Critical Care Medicine

Pulmonary fibrosis and COVID-19: the potential role for antifibrotic therapy

Peter M. George et al.

LANCET RESPIRATORY MEDICINE (2020)

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Article Oncology

Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection

Zou Xin et al.

FRONTIERS OF MEDICINE (2020)

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Article Biochemistry & Molecular Biology

SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes

Waradon Sungnak et al.

NATURE MEDICINE (2020)

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Article Medicine, General & Internal

Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19

Maximilian Ackermann et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Editorial Material Medicine, General & Internal

Covid-19, Angiogenesis, and ARDS Endotypes

Lida Hariri et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Letter Medicine, General & Internal

Clinical Characteristics of Covid-19 in New York City

Parag Goyal et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Editorial Material Physiology

Demystifying pulmonary fibrosis

Gisli Jenkins

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2020)

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Letter Critical Care Medicine

Heterogeneity of Acute Respiratory Distress Syndrome in COVID-19: Typical or Not?

Jason H. Maley et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2020)

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Letter Critical Care Medicine

COVID-19-related Acute Respiratory Distress Syndrome: Not So Atypical

Lieuwe D. J. Bos

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2020)

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Letter Critical Care Medicine

Respiratory Mechanics of COVID-19-versus Non-COVID-19-associated Acute Respiratory Distress Syndrome

Anne-Fleur Haudebourg et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2020)

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Article Medicine, General & Internal

Obesity and Mortality Among Patients Diagnosed With COVID-19: Results From an Integrated Health Care Organization

Sara Y. Tartof et al.

ANNALS OF INTERNAL MEDICINE (2020)

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Editorial Material Respiratory System

Endothelial cell dysfunction: a major player in SARS-CoV-2 infection (COVID-19)?

Alice Huertas et al.

EUROPEAN RESPIRATORY JOURNAL (2020)

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Editorial Material Pharmacology & Pharmacy

New Strategy for COVID-19: An Evolutionary Role for RGD Motif in SARS-CoV-2 and Potential Inhibitors for Virus Infection

Shijia Yan et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Letter Medicine, General & Internal

Persistent Symptoms in Patients After Acute COVID-19

Angelo Carfi et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

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Article Multidisciplinary Sciences

Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis

Taylor S. Adams et al.

SCIENCE ADVANCES (2020)

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Article Multidisciplinary Sciences

Single-cell RNA sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosis

Arun C. Habermann et al.

SCIENCE ADVANCES (2020)

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Review Infectious Diseases

A comparison of mortality-related risk factors of COVID-19, SARS, and MERS: A systematic review and meta-analysis

Lvliang Lu et al.

JOURNAL OF INFECTION (2020)

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Article Critical Care Medicine

Compliance Phenotypes in Early Acute Respiratory Distress Syndrome before the COVID-19 Pandemic

Rakshit Panwar et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2020)

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Article Biochemistry & Molecular Biology

Cellular Microenvironment Stiffness Regulates Eicosanoid Production and Signaling Pathways

Asres Berhan et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2020)

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Letter Infectious Diseases

Lung fibrosis: an undervalued finding in COVID-19 pathological series

Federica Grillo et al.

LANCET INFECTIOUS DISEASES (2020)

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Article Infectious Diseases

Estimates of the severity of coronavirus disease 2019: a model-based analysis

Robert Verity et al.

LANCET INFECTIOUS DISEASES (2020)

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Article Biotechnology & Applied Microbiology

COVID-19 severity correlates with airway epithelium-immune cell interactions identified by single-cell analysis

Robert Lorenz Chua et al.

NATURE BIOTECHNOLOGY (2020)

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Review Biochemistry & Molecular Biology

Extrapulmonary manifestations of COVID-19

Aakriti Gupta et al.

NATURE MEDICINE (2020)

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Article Multidisciplinary Sciences

Alveolar regeneration through a Krt8+transitional stem cell state that persists in human lung fibrosis

Maximilian Strunz et al.

NATURE COMMUNICATIONS (2020)

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Editorial Material Medicine, General & Internal

Long-term Health Consequences of COVID-19

Carlos del Rio et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

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Review Medicine, General & Internal

Spectrum of Fibrotic Lung Diseases

Marlies Wijsenbeek et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Multidisciplinary Sciences

Translational pharmacology of an inhaled small molecule αvβ6 integrin inhibitor for idiopathic pulmonary fibrosis

Alison E. John et al.

NATURE COMMUNICATIONS (2020)

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Article Critical Care Medicine

Pathophysiology of COVID-19-associated acute respiratory distress syndrome: a multicentre prospective observational study

Giacomo Grasselli et al.

LANCET RESPIRATORY MEDICINE (2020)

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Review Biochemistry & Molecular Biology

Endothelial Damage in Acute Respiratory Distress Syndrome

Alice G. Vassiliou et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Cell Biology

Lung transplantation for patients with severe COVID-19

Ankit Bharat et al.

SCIENCE TRANSLATIONAL MEDICINE (2020)

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Review Cell Biology

Fibroblast Senescence in Idiopathic Pulmonary Fibrosis

Yifan Lin et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

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Review Medicine, General & Internal

Senescence in Pulmonary Fibrosis: Between Aging and Exposure

Alessandro Venosa

FRONTIERS IN MEDICINE (2020)

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Review Respiratory System

From SARS and MERS to COVID-19: a brief summary and comparison of severe acute respiratory infections caused by three highly pathogenic human coronaviruses

Zhixing Zhu et al.

RESPIRATORY RESEARCH (2020)

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Article Immunology

Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages

Miriam Merad et al.

NATURE REVIEWS IMMUNOLOGY (2020)

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Article Medicine, General & Internal

Follow-up study of the pulmonary function and related physiological characteristics of COVID-19 survivors three months after recovery

Yu-miao Zhao et al.

ECLINICALMEDICINE (2020)

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Article Respiratory System

Cellular senescence and senescence-associated secretory phenotype: comparison of idiopathic pulmonary fibrosis, connective tissue disease-associated interstitial lung disease, and chronic obstructive pulmonary disease

Ryo Okuda et al.

JOURNAL OF THORACIC DISEASE (2019)

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Article Medicine, General & Internal

Acute respiratory distress syndrome

Michael A. Matthay et al.

NATURE REVIEWS DISEASE PRIMERS (2019)

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Article Critical Care Medicine

Is Progression of Pulmonary Fibrosis due to Ventilation-induced Lung Injury?

Richard K. Albert et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2019)

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Article Critical Care Medicine

Resequencing Study Confirms That Host Defense and Cell Senescence Gene Variants Contribute to the Risk of Idiopathic Pulmonary Fibrosis

Camille Moore et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2019)

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Review Critical Care Medicine

Acute Respiratory Distress Syndrome Phenotypes

John P. Reilly et al.

SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE (2019)

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Article Respiratory System

Dysregulated expression of hypoxia-inducible factors augments myofibroblasts differentiation in idiopathic pulmonary fibrosis

Arnoldo Aquino-Galvez et al.

RESPIRATORY RESEARCH (2019)

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Article Medicine, Research & Experimental

Registration of the extracellular matrix components constituting the fibroblastic focus in idiopathic pulmonary fibrosis

Jeremy Herrera et al.

JCI INSIGHT (2019)

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Review Physiology

Fibroblast senescence in the pathology of idiopathic pulmonary fibrosis

David W. Waters et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2018)

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Letter Critical Care Medicine

MUC5B Promoter Polymorphism and Development of Acute Respiratory Distress Syndrome

Angela J. Rogers et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2018)

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Article Biochemistry & Molecular Biology

Fibroblast–Matrix Cross-Talk in Idiopathic Pulmonary Fibrosis: Cross-Links at the Crossroads

Peter Bitterman

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2018)

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Article Biochemistry & Molecular Biology

Involvement of Alveolar Epithelial Cell Necroptosis in Idiopathic Pulmonary Fibrosis Pathogenesis

Ji-Min Lee et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2018)

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Article Biochemistry & Molecular Biology

Extracellular Matrix Cross-Linking Enhances Fibroblast Growth and Protects against Matrix Proteolysis in Lung Fibrosis

Christopher J. Philp et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2018)

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Letter Respiratory System

Gadofosveset-enhanced lung magnetic resonance imaging to detect ongoing vascular leak in pulmonary fibrosis

Sydney B. Montesi et al.

EUROPEAN RESPIRATORY JOURNAL (2018)

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Review Medicine, Research & Experimental

Extracellular matrix as a driver of progressive fibrosis

Jeremy Herrera et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

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Review Medicine, Research & Experimental

Mechanosensing and fibrosis

Daniel J. Tschumperlin et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

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Review Medicine, General & Internal

Idiopathic Pulmonary Fibrosis

David J. Lederer et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

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Article Multidisciplinary Sciences

Hypoxia induces pulmonary fibroblast proliferation through NFAT signaling

Lakmini Kumari Senavirathna et al.

SCIENTIFIC REPORTS (2018)

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Article Multidisciplinary Sciences

Muc5b overexpression causes mucociliary dysfunction and enhances lung fibrosis in mice

Laura A. Hancock et al.

NATURE COMMUNICATIONS (2018)

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Article Respiratory System

Matrix abnormalities in pulmonary fibrosis

Chandak Upagupta et al.

EUROPEAN RESPIRATORY REVIEW (2018)

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Article Medicine, Research & Experimental

Localized hypoxia links ER stress to lung fibrosis through induction of C/EBP homologous protein

Ankita Burman et al.

JCI INSIGHT (2018)

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Review Medicine, General & Internal

Idiopathic pulmonary fibrosis

Luca Richeldi et al.

LANCET (2017)

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Article Cell Biology

Local lung hypoxia determines epithelial fate decisions during alveolar regeneration

Ying Xi et al.

NATURE CELL BIOLOGY (2017)

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Review Medicine, General & Internal

Acute Respiratory Distress Syndrome

B. Taylor Thompson et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

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Article Multidisciplinary Sciences

Cellular senescence mediates fibrotic pulmonary disease

Marissa J. Schafer et al.

NATURE COMMUNICATIONS (2017)

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Review Medicine, General & Internal

Genetics in idiopathic Pulmonary Fibrosis Pathogenesis, Prognosis, and Treatment

Amarpreet Kaur et al.

FRONTIERS IN MEDICINE (2017)

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Article Critical Care Medicine

Toward Smarter Lumping and Smarter Splitting: Rethinking Strategies for Sepsis and Acute Respiratory Distress Syndrome Clinical Trial Design

Hallie C. Prescott et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2016)

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Article Biochemistry & Molecular Biology

Targeting of the pulmonary capillary vascular niche promotes lung alveolar repair and ameliorates fibrosis

Zhongwei Cao et al.

NATURE MEDICINE (2016)

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Review Physiology

IDIOPATHIC PULMONARY FIBROSIS: A GENETIC DISEASE THAT INVOLVES MUCOCILIARY DYSFUNCTION OF THE PERIPHERAL AIRWAYS

Christopher M. Evans et al.

PHYSIOLOGICAL REVIEWS (2016)

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Review Respiratory System

The pulmonary endothelium in acute respiratory distress syndrome: insights and therapeutic opportunities

Fraser R. Millar et al.

THORAX (2016)

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Article Physiology

Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis

Fei Liu et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2015)

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Article Biochemistry & Molecular Biology

Alveolar Derecruitment and Collapse Induration as Crucial Mechanisms in Lung Injury and Fibrosis

Dennis Lutz et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2015)

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Article Critical Care Medicine

The MUC5B Promoter Polymorphism Is Associated With Idiopathic Pulmonary Fibrosis in a Mexican Cohort but Is Rare Among Asian Ancestries

Anna L. Peljto et al.

CHEST (2015)

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Article Respiratory System

The genetic basis of idiopathic pulmonary fibrosis

Jonathan A. Kropski et al.

EUROPEAN RESPIRATORY JOURNAL (2015)

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Article Respiratory System

MUC5B promoter polymorphism in Japanese patients with idiopathic pulmonary fibrosis

Yasushi Horimasu et al.

RESPIROLOGY (2015)

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Article Multidisciplinary Sciences

Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury

Andrew E. Vaughan et al.

NATURE (2015)

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Article Respiratory System

MUC5B and Idiopathic Pulmonary Fibrosis

Ivana V. Yang et al.

ANNALS OF THE AMERICAN THORACIC SOCIETY (2015)

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Review Anesthesiology

Mechanical Ventilation-associated Lung Fibrosis in Acute Respiratory Distress Syndrome A Significant Contributor to Poor Outcome

Nuria E. Cabrera-Benitez et al.

ANESTHESIOLOGY (2014)

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Review Respiratory System

The fibroproliferative response in acute respiratory distress syndrome: mechanisms and clinical significance

Ellen L. Burnham et al.

EUROPEAN RESPIRATORY JOURNAL (2014)

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Article Medicine, General & Internal

A Phase 3 Trial of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis

Talmadge E. King et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

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Article Medicine, General & Internal

Efficacy and Safety of Nintedanib in Idiopathic Pulmonary Fibrosis

Luca Richeldi et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

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Article Critical Care Medicine

Comparison of the Berlin Definition for Acute Respiratory Distress Syndrome with Autopsy

Arnaud W. Thille et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2013)

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Article Biochemistry & Molecular Biology

Matrices of Physiologic Stiffness Potently Inactivate Idiopathic Pulmonary Fibrosis Fibroblasts

Aleksandar Marinkovic et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2013)

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Review Medicine, Research & Experimental

Molecular Mechanisms in Progressive Idiopathic Pulmonary Fibrosis

Mark P. Steele et al.

ANNUAL REVIEW OF MEDICINE, VOL 64 (2013)

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Article Critical Care Medicine

Chest CT Features are Associated With Poorer Quality of Life in Acute Lung Injury Survivors

Ellen L. Burnham et al.

CRITICAL CARE MEDICINE (2013)

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Article Medicine, General & Internal

Association Between the MUC5B Promoter Polymorphism and Survival in Patients With Idiopathic Pulmonary Fibrosis

Anna L. Peljto et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2013)

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Article Medicine, Research & Experimental

Type 2 alveolar cells are stem cells in adult lung

Christina E. Barkauskas et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

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Article Genetics & Heredity

Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis

Tasha E. Fingerlin et al.

NATURE GENETICS (2013)

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Review Medicine, General & Internal

Ventilator-Induced Lung Injury

Arthur S. Slutsky et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

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Article Multidisciplinary Sciences

The MUC5B Variant Is Associated with Idiopathic Pulmonary Fibrosis but Not with Systemic Sclerosis Interstitial Lung Disease in the European Caucasian Population

Raphael Borie et al.

PLOS ONE (2013)

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Article Respiratory System

Mucin 5B promoter polymorphism is associated with idiopathic pulmonary fibrosis but not with development of lung fibrosis in systemic sclerosis or sarcoidosis

Carmel J. Stock et al.

THORAX (2013)

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Article Critical Care Medicine

Chronology of histological lesions in acute respiratory distress syndrome with diffuse alveolar damage: a prospective cohort study of clinical autopsies

Arnaud W. Thille et al.

LANCET RESPIRATORY MEDICINE (2013)

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Article Critical Care Medicine

The Berlin definition of ARDS: an expanded rationale, justification, and supplementary material

Niall D. Ferguson et al.

INTENSIVE CARE MEDICINE (2012)

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Article Radiology, Nuclear Medicine & Medical Imaging

Post-ARDS pulmonary fibrosis in patients with H1N1 pneumonia: role of follow-up CT

G. Mineo et al.

RADIOLOGIA MEDICA (2012)

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Article Critical Care Medicine

Quality of Life, Pulmonary Function, and Tomographic Scan Abnormalities After ARDS

Joan R. Masclans et al.

CHEST (2011)

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Letter Medicine, General & Internal

A Variant in the Promoter of MUC5B and Idiopathic Pulmonary Fibrosis

Yingze Zhang et al.

NEW ENGLAND JOURNAL OF MEDICINE (2011)

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Article Medicine, General & Internal

A Common MUC5B Promoter Polymorphism and Pulmonary Fibrosis

Max A. Seibold et al.

NEW ENGLAND JOURNAL OF MEDICINE (2011)

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Article Medicine, General & Internal

Functional Disability 5 Years after Acute Respiratory Distress Syndrome

Margaret S. Herridge et al.

NEW ENGLAND JOURNAL OF MEDICINE (2011)

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Article Multidisciplinary Sciences

Endoplasmic reticulum stress enhances fibrotic remodeling in the lungs

William E. Lawson et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

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Article Critical Care Medicine

Targeted Injury of Type II Alveolar Epithelial Cells Induces Pulmonary Fibrosis

Thomas H. Sisson et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2010)

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Article Respiratory System

The long-term impact of severe acute respiratory syndrome on pulmonary function, exercise capacity and health status

Jenny C. Ngai et al.

RESPIROLOGY (2010)

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Article Critical Care Medicine

Partial inhibition of integrin alpha v beta 6 prevents pulmonary fibrosis without exacerbating inflammation

Gerald S. Horan et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2008)

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Article Critical Care Medicine

Telomere shortening in familial and sporadic pulmonary fibrosis

Jennifer T. Cronkhite et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2008)

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Article Critical Care Medicine

Effects of mechanical ventilation on the extracellular matrix

Paolo Pelosi et al.

INTENSIVE CARE MEDICINE (2008)

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Article Critical Care Medicine

Advances in mechanisms of repair and remodelling in acute lung injury

Claudia C. Dos Santos

INTENSIVE CARE MEDICINE (2008)

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Article Multidisciplinary Sciences

Short telomeres are a risk factor for idiopathic pulmonary fibrosis

Jonathan K. Alder et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

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Article Respiratory System

The role of integrins in pulmonary fibrosis

D. Sheppard

EUROPEAN RESPIRATORY REVIEW (2008)

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Article Genetics & Heredity

A genome-wide association study identifies an association of a common variant in TERT with susceptibility to idiopathic pulmonary fibrosis

T. Mushiroda et al.

JOURNAL OF MEDICAL GENETICS (2008)

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Article Multidisciplinary Sciences

Adult-onset pulmonary fibrosis caused by mutations in telomerase

Kalliopi D. Tsakiri et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

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Article Medicine, General & Internal

Telomerase mutations in families with idiopathic pulmonary fibrosis

Mary Y. Armanios et al.

NEW ENGLAND JOURNAL OF MEDICINE (2007)

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Article Respiratory System

Impact of severe acute respiratory syndrome (SARS) on pulmonary function, functional capacity and quality of life in a cohort of survivors

DS Hui et al.

THORAX (2005)

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Article Biochemistry & Molecular Biology

Apoptosis and necrosis induced by cyclic mechanical stretching in alveolar type II cells

S Hammerschmidt et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2004)

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Article Immunology

Pulmonary edema fluid from patients with early lung injury stimulates fibroblast proliferation through IL-1β-induced IL-6 expression

MA Olman et al.

JOURNAL OF IMMUNOLOGY (2004)

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Article Oncology

Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis

I Hamming et al.

JOURNAL OF PATHOLOGY (2004)

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Article Radiology, Nuclear Medicine & Medical Imaging

Thin-section CT in patients with severe acute respiratory syndrome following hospital discharge: Preliminary experience

GE Antonio et al.

RADIOLOGY (2003)

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Article Respiratory System

Bleomycin induces cellular senescence in alveolar epithelial cells

K Aoshiba et al.

EUROPEAN RESPIRATORY JOURNAL (2003)

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Article Respiratory System

Ventilator-induced lung injury

JD Ricard et al.

EUROPEAN RESPIRATORY JOURNAL (2003)

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Article Critical Care Medicine

Efficacy of low tidal volume ventilation in patients with different clinical risk factors for acute lung injury and the acute respiratory distress syndrome

MD Eisner et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2001)

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Article Pathology

Evidence of type II pneumocyte apoptosis in the pathogenesis of idiopathic pulmonary fibrosis (IFP)/usual interstitial pneumonia (UIP)

JV Barbas-Filho et al.

JOURNAL OF CLINICAL PATHOLOGY (2001)

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Article Radiology, Nuclear Medicine & Medical Imaging

Changes in lung parenchyma after acute respiratory distress syndrome (ARDS): assessment with high-resolution computed tomography

IM Nobauer-Huhmann et al.

EUROPEAN RADIOLOGY (2001)

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