期刊
TRANSLATIONAL ONCOLOGY
卷 14, 期 8, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.tranon.2021.101134
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资金
- international doctoral program iTarget - Elite Network of Bavaria
- Melanoma Research Alliance [N269626, 409510]
- Marie-Sklodowska-Curie Training Network for the Immunotherapy of Cancer (IMMU-TRAIN) - H2020 program of the European Union
- Marie-Sklodowska-Curie Training Network for Optimizing Adoptive T cell Therapy (TOP) - H2020 program of the European Union
- Else Kroner-Fresenius-Stiftung
- German Cancer Aid
- Ernst-Jung-Stiftung
- Bundesministerium flir Bildung und Forschung VIP + grant ONKATTRACT
- European Research Council [756017]
- Deutsche Forschungsgemeinschaft (DFG)
- Jose Carreras Foundation
- Hector Foundation
- Fritz-Bender Foundation
Research has shown that lncRNAs play roles in various physiological and pathological events, including immune system regulation and cancer; while CSCs, as a group of cancer cells with specific characteristics, are crucial for tumor growth and progression in conjunction with the cancer microenvironment, genetics, and epigenetics.
In recent years, it has been evidenced that the human transcriptome includes several types of non-coding RNAs (ncRNAs) that are mainly involved in the regulation of different cellular processes. Among ncRNAs, long-non-coding RNAs (lncRNAs) are defined as longer than 200 nucleotides and have been shown to be involved in several physiological and pathological events, including immune system regulation and cancer. Cancer stem cells (CSCs) are defined as a population of cancer cells that possess characteristics, such as resistance to standard treatments, cancer initiation, ability to undergo epithelial-to-mesenchymal transition, and the ability to invade, spread, and generate metastases. The cancer microenvironment, together with genetic and epigenetic factors, is fundamental for CSC maintenance and tumor growth and progression. Unsurprisingly, lncRNAs have been involved in both CSC biology and cancer progression, prognosis and recurrence. Here we review the most recent literature on IncRNAs involvement in CSC biology and function.
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