SARS-CoV-2 antibody persistence in COVID-19 convalescent plasma donors: Dependency on assay format and applicability to serosurveillance

Article Immunology

Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Antibody Avidity Maturation and Association with Disease Severity

Yiqi Ruben Luo et al.

Summary: The study revealed a correlation between the kinetics of IgG avidity maturation and days since symptom onset during SARS-CoV-2 infection, with significantly higher peak readings in severe cases compared to mild cases.

CLINICAL INFECTIOUS DISEASES (2021)

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Review Microbiology

The Importance and Challenges of Identifying SARS-CoV-2 Reinfections

Ahmed Babiker et al.

Summary: Reports of SARS-CoV-2 reinfection have raised questions about the immune response and the possibility of partial immune protection. Further research is needed to elucidate the frequency, determinants, and consequences of these reinfections. Collaborative efforts involving clinical laboratories and investigators are crucial to establish frameworks for surveillance and investigation.

JOURNAL OF CLINICAL MICROBIOLOGY (2021)

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Article Multidisciplinary Sciences

Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection

Jennifer M. Dan et al.

Summary: Different components of immune memory to SARS-CoV-2 exhibit distinct kinetics, with antibodies and spike-specific memory B cells remaining relatively stable over 6 months, while CD4(+) T cells and CD8(+) T cells declining with a half-life of 3 to 5 months after infection.

SCIENCE (2021)

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Article Multidisciplinary Sciences

Three-quarters attack rate of SARS-CoV-2 in the Brazilian Amazon during a largely unmitigated epidemic

Lewis F. Buss et al.

Summary: Research indicates that the attack rate of COVID-19 in Manaus, the capital of Amazonas state in northern Brazil, reached 66% in June 2020, rising to 76% by October, higher than the estimated attack rate of 29% in Sao Paulo, southeastern Brazil, during the same period.

SCIENCE (2021)

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Review Immunology

SARS-CoV-2 Serologic Assay Needs for the Next Phase of the US COVID-19 Pandemic Response

Adi Gundlapalli et al.

Summary: There is a current lack of standardized SARS-CoV-2 quantitative IgG and neutralization assays, which hinders the comparison of results from different studies. Most studies have used in-house laboratory-developed tests with non-standardized reporting methods. It is vital to enhance interassay and interlaboratory validation and standardization in order to better understand immune responses and vaccine efficacy.

OPEN FORUM INFECTIOUS DISEASES (2021)

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Article Allergy

Systemic and mucosal antibody responses specific to SARS-CoV-2 during mild versus severe COVID-19

Carlo Cervia et al.

Summary: The study found that severe COVID-19 patients experienced a significant increase in SARS-CoV-2 antibody titers after symptom onset, especially with high IgA titers, while mild cases may exhibit transient production of SARS-CoV-2-specific antibodies. Interestingly, some healthcare workers with negative serum antibody titers showed SARS-CoV-2-specific IgA in mucosal fluids with virus-neutralizing capacity in some cases.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Article Hematology

Selecting COVID-19 convalescent plasma for neutralizing antibody potency using a high-capacity SARS-CoV-2 antibody assay

Erin Goodhue Meyer et al.

Summary: The efficacy of COVID-19 convalescent plasma (CCP) is believed to be linked to the concentration of neutralizing antibodies (nAb) to SARS-CoV-2. A study found that using surrogate binding antibody (bAb) signal-to-cutoff ratios (S/Co) to predict nAb titers can be effective, but the accuracy of the prediction decreases as target nAb titers increase.

TRANSFUSION (2021)

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Article Microbiology

A SARS-CoV-2 Label-Free Surrogate Virus Neutralization Test and a Longitudinal Study of Antibody Characteristics in COVID-19 Patients

Yiqi Ruben Luo et al.

Summary: LF-sVNT test analyzes the changes in neutralizing antibody titers, IgG concentrations, and IgG avidity indices in COVID-19 patients, revealing a decline in IgG concentrations and neutralizing antibody titers after 40 days, while the IgG avidity index remains stable. LF-sVNT can serve as a valuable tool for assessing the presence of neutralizing antibodies to COVID-19.

JOURNAL OF CLINICAL MICROBIOLOGY (2021)

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Letter Immunology

Waning Antibody Responses in Asymptomatic and Symptomatic SARS-CoV-2 Infection

Pyoeng Gyun Choe et al.

Summary: The kinetics of SARS-CoV-2 neutralizing antibodies were investigated in asymptomatic individuals and pneumonia patients, showing a decline in antibody titer from 219.4 at 2 months to 143.7 at 5 months after infection, indicating a waning antibody response.

EMERGING INFECTIOUS DISEASES (2021)

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Article Biochemistry & Molecular Biology