期刊
TRANSBOUNDARY AND EMERGING DISEASES
卷 69, 期 4, 页码 E20-E31出版社
WILEY-HINDAWI
DOI: 10.1111/tbed.14258
关键词
alleles; chronic; deer; genetic variation; Norway; prion proteins; wasting disease
资金
- NorgesMiljo-og Biovitenskapelige Universitet
- NordForsk
- Veterinaerinstituttet
- Miljodirektoratet
The susceptibility of cervids to Chronic Wasting Disease (CWD) in Norway is modulated by variations in the prion protein gene (PRNP), with different species having different levels of susceptibility. The PRNP genetic data indicate considerable susceptibility to CWD among Norwegian cervids, and suggest that PRNP homozygosity may be a risk factor for the atypical CWD observed in moose. The CWD isolates found in Norwegian cervids differ from those previously found in Canada and USA, indicating potential strain dynamics related to PRNP variability.
Susceptibility of cervids to Chronic Wasting Disease (CWD), a prion disease, can be modulated by variations in the prion protein gene (PRNP), encoding the cellular prion protein (PrP(C)). In prion diseases, PrP(C) is conformationally converted to pathogenic conformers (PrPSc), aggregates of which comprise infectious prions. CWD has recently been observed in its contagious form in Norwegian reindeer (Rangifer tarandus) and in novel, potentially sporadic forms, here called 'atypical CWD', in moose (Alces alces) and red deer (Cervus elaphus). To estimate relative susceptibility of different Norwegian cervid species to CWD, their non-synonymous PRNP variants were analyzed. In reindeer, seven PRNP alleles were observed and in red deer and moose two alleles were present, whereas roe deer (Capreolus capreolus) PRNP was monomorphic. One 'archetypal' PRNP allele associated with susceptibility was common to all four cervid species. The distribution of PRNP alleles differed between wild and semi-domesticated reindeer, with alleles associated with a high susceptibility occurring, on average, above 55% in wild reindeer and below 20% in semi-domesticated reindeer. This difference may reflect the diverse origins of the populations and/or selection processes during domestication and breeding. Overall, PRNP genetic data indicate considerable susceptibility to CWD among Norwegian cervids and suggest that PRNP homozygosity may be a risk factor for the atypical CWD observed in moose. The CWD isolates found in the Norwegian cervid species differ from those previously found in Canada and USA. Our study provides an overview of the PRNP genetics in populations exposed to these emerging strains that will provide a basis for understanding these strains' dynamics in relation to PRNP variability.
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