期刊
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
卷 141, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2021.116284
关键词
Dilute-and-shoot; Liquid chromatography; Mass spectrometry; Sample preparation; Food analysis; Bioanalysis; Mycotoxin; Multi-class
资金
- Agritox
- Interreg Atlantic Area Programme through the European Regional Development Fund [EAPA 998/2018]
- InvestNI [111217001]
With laboratories seeking to expand analytical capabilities, there has been a shift towards generic sample clean-up techniques like dilute-and-shoot. This methodology is simple, versatile, and facilitates high sample throughput and analysis of various analyte classes.
ABSTR A C T With laboratories seeking to expand analytical capabilities and create multi-class, multi-analyte methods, there has been a shift toward generic sample clean-up techniques such as dilute-and-shoot. Advantages of this methodology include its simplicity, minimal analyte losses, high sample throughput and number of analyte classes included. The evolution of dilute-and-shoot has permitted its use across a variety of matrices including food and biological and in various scientific fields such as food, forensics and environmental. The versatility of the technique permits the expansion of current fields of research without the usual laborious method development. There can be issues with matrix effects and robust quantitation as analyte number increases. This review provides an overview of the technique combined with liquid chromatography mass spectrometry, highlighting its power in facilitating multi-class anal-ysis. Coupled with increases in instrument performance there is potential to employ this methodology in expanding analytical capabilities in many areas of life science research. (c) 2021 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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