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Dysregulation of cellular energetics in Gulf War Illness

期刊

TOXICOLOGY
卷 461, 期 -, 页码 -

出版社

ELSEVIER IRELAND LTD
DOI: 10.1016/j.tox.2021.152894

关键词

Mitochondrial function; Chronic fatigue; Gulf war; Gulf war illness; Pyridostigmine bromide; Permethrin; mitoQ; Multi-symptom illness

资金

  1. Department of Defense Gulf War Illness program [W81XWH2110244]

向作者/读者索取更多资源

Gulf War Illness (GWI) affects a significant number of veterans from the first Persian Gulf War, with common symptoms including chronic neurological impairments and fatigue syndrome. Despite the lack of effective treatments, research on mitochondrial dysfunction and cellular energetics provides promising implications for developing therapeutic strategies. Further studies are needed to understand the underlying pathology and develop new treatment methods for GWI.
Gulf War Illness (GWI) is estimated to have affected about one third of the Veterans who participated in the first Persian Gulf War. The symptoms of GWI include chronic neurologic impairments, chronic fatigue syndrome, as well as fibromyalgia and immune system disorders, collectively referred to as chronic multi-symptom illness. Thirty years after the war, we still do not have an effective treatment for GWI. It is necessary to understand the molecular basis of the symptoms of GWI in order to develop appropriate therapeutic strategies. Cellular energetics are critical to the maintenance of cellular homeostasis, a process that is highly dependent on intact mitochondrial function and there is significant evidence from both human studies and animal models that mitochondrial impairments may lead to GWI symptoms. The available clinical and pre-clinical data suggest that agents that improve mitochondrial function have the potential to restore cellular energetics and treat GWI. To date, the experiments conducted in animal models of GWI have mainly focused on neurobehavioral aspects of the illness. Additional studies to address the fundamental biological processes that trigger the dysregulation of cellular energetics in GWI are warranted to better understand the underlying pathology and to develop new treatment methods. This review highlights studies related to mitochondrial dysfunction observed in both GW veterans and in animal models of GWI.

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