Synthesis of azaxanthones via DDQ-mediated tandem oxidative annulation

A DDQ-mediated tandem annulation of 2-aminochromones with 1,3-diarylpropenes is disclosed, which provides the azaxanthones in moderate to good yields. The oxidative coupling, intramolecular cyclization and dehydro-aromatization might be involved in this high atom-efficiency reaction. (c) 2021 Elsevier Ltd. All rights reserved.

Automated summary

A DDQ-mediated tandem annulation of 2-aminochromones with 1,3-diarylpropenes is described for the synthesis of azaxanthones in moderate to good yields. The reaction involves oxidative coupling, intramolecular cyclization, and dehydro-aromatization, showcasing high atom efficiency.