One-pot, two-step synthesis of 3,4-dihydroquinazoline-2(1H)-thiones from o-azidobenzenealdehydes, aryl amines and carbon disulfide

A one-pot, two-step method was developed for the synthesis of 3-aryl-3,4-dihydroquinazoline-2(1H)-thiones involving the reductive amination of o-azidobenzaldehydes and aryl amines followed by the Staudinger-aza-Wittig reaction with CS2. (C) 2021 Elsevier Ltd. All rights reserved.

Automated summary

This method involves the reductive amination of o-azidobenzaldehydes and aryl amines followed by the Staudinger-aza-Wittig reaction with CS2 to synthesize 3-aryl-3,4-dihydroquinazoline-2(1H)-thiones in one pot and two steps.