Solvent-free preparation of α,α-dichloroketones with sulfuryl chloride

An efficient and facile method is reported for the synthesis of a series of alpha,alpha-dichloroketones. The direct dichlorination of methyl ketones and 1,3-dicarbonyls using an excess amount of sulfuryl chloride affords the corresponding gemdichloro compounds in moderate to excellent yields. Moreover, the protocol features high yields, broad substrate scope, and simple reaction conditions without using any catalysts and solvents. (C) 2021 Elsevier Ltd. All rights reserved.

Automated summary

An efficient and facile method for the synthesis of a series of alpha,alpha-dichloroketones was reported. The protocol features high yields, broad substrate scope, and simple reaction conditions without using any catalysts and solvents.