期刊
TETRAHEDRON LETTERS
卷 81, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2021.153364
关键词
Flow synthesis; Phosphate ester; Phosphite ester; High productivity; Flash chemistry
资金
- JSPSKAKENHI [JP15H05849, JP26288049, JP26220804, JP25220913, JP17865428, JP20K15276]
- AMED [JP19ak0101090]
- Japan Science and Technology Agency's (JST) A-step program [18067420]
- CREST
- Ogasawara Foundation for the Promotion of Science Engineering
This study focused on transforming the commonly heterogeneous synthesis of phosphate esters into homogeneous synthesis, achieving high productivity in flow systems. Results showed that accelerating the reaction rate can further increase productivity. Additionally, the synthesis of the Akiyama-Terada catalyst was successfully completed in a short period.
Flow synthesis techniques have received a significant amount of attention due to their high productivity. However, when reaction condition is heterogeneous, it is usually difficult to adapt it to flow synthesis. Herein, by selecting appropriate reagents, the synthesis of phosphate esters, which is commonly heterogeneous, was made homogeneous, enabling synthesis in flow systems. In addition, reaction rate was accelerated compared to the batch system. It was demonstrated that not only can the high productivity of flow synthesis be achieved in flow, but also high productivity can be achieved by accelerating the reaction. Finally, we demonstrated the synthesis of the Akiyama-Terada catalyst, a chiral organocatalysts, in a short period. (c) 2021 Published by Elsevier Ltd.
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