Two Erythrina alkaloids and three diarylpropanoids from Erythrina velutina

Two new Erythrina alkaloid glycosides, 1 and 2, and three new diarylpropanoid glycosides 12-14 together with nine known compounds were isolated from the MeOH extracts of the seeds of Erythrina velutina. The structures and absolute configurations of these new compounds were elucidated through comprehensive spectroscopic analyses as well as experimental and calculated ECD data. The inhibitory potency of these compounds against nitric oxide production in LPS-induced RAW 264.7 cells and the cytotoxicity of these compounds against the HeLa and HL-60 human cancer cell lines were also discussed. (c) 2021 Elsevier Ltd. All rights reserved.

Automated summary

Two new Erythrina alkaloid glycosides and three new diarylpropanoid glycosides, along with nine known compounds, were isolated from the seeds of Erythrina velutina. The structures and absolute configurations of these new compounds were elucidated through comprehensive spectroscopic analyses and experimental and calculated ECD data. The inhibitory potency of these compounds against nitric oxide production in LPS-induced RAW 264.7 cells and their cytotoxicity against HeLa and HL-60 human cancer cell lines were also discussed.