New iridoid and phenylethanoid glycosides from the roots of Scrophularia ningpoensis

Two new iridoid glycosides, scrophularosides A and B (1-2), two phenylethanoid glycosides, scrophularosides C-D (3-4) and eight known compounds (5-12) were isolated from the roots of Scrophularia ningpoensis. Their structures were elucidated via the interpretation of spectroscopic methods, especially 2D NMR and mass analyses. Compound 1 was a novel iridoid glycoside which possessed a 5/6/7/6 ring system with an unprecedented trioxabicyclo [4.3.1] decane core. The anti-inflammatory potential of new compounds 1-4 was evaluated by determining their ability to inhibit lipopolysaccharide (LPS) induced NO production in RAW 264.7 macrophage cells. (c) 2021 Elsevier Ltd. All rights reserved.

Automated summary

Two new iridoid glycosides and two phenylethanoid glycosides were isolated from Scrophularia ningpoensis roots. The structures were determined through spectroscopic methods, with compound 1 identified as a novel iridoid glycoside with potential anti-inflammatory activity.